Endocrine Abstracts

Hypoxia-inducible factor (HIF)-1α plays an important role in cancer progression. In various cancers, including thyroid cancer, overexpression of HIF-1α is related to poor prognosis or treatment response. However, few studies have investigated the role of HIF-1α inhibition in thyroid cancer progression. We evaluated the utility of the HIF-1α inhibitor IDF-11774 in vitro utilizing two thyroid cancer cell lines, K1 and BCPAP. Both cell lines were test...

Background: The incidence and mortality rates of thyroid cancer have shown a significant upward trend. However, the current understanding of risk factors associated with thyroid cancer remains ambiguous and inconclusive. This umbrella review aims to identify the relationships between non-genetic risk factors and thyroid cancer incidence, while also evaluating the quality and validity of existing evidence.Methods: This umbrella review was performed accord...

The thyroid differentiation score (TDS), calculated on the expression levels of 16 thyroid metabolism and function genes, was introduced by the Cancer Genome Atlas to characterize the differentiation status in papillary thyroid carcinoma (PTC). TDS has been reported to be significantly lower in BRAF-like than in RAS-like PTCs. Nevertheless, scanty data are available about TDS in either other malignant cancers or in benign thyroid nodules. The aim of the present study was to an...

Background: If the prognosis of papillary thyroid microcarcinoma(PTMC) is favorable, when the central lymph node metastasis is suspected with active surveillance without surgery, it is advisable to comteplate surgery. Therefore, this study investigate the gene mutations involved in central lymph node metatstasis in papillary microcarcinoma.Methods: DNA was obtained from the primary tumor tissues of of 36 PTMC with those of central neck lymph nodes metast...

Objectives: ETS-1 (E26 transformation-specific) is a transcription factor associated with the progression of carcinomas of various origins. Its expression in PTC is poorly described, and the findings are controversial. This study aimed to describe ETS-1 protein expression in papillary thyroid carcinoma (PTC) and to evaluate the potential influence of miR-204-3p on the ETS-1 protein expression in PTC since the bioinformatic analysis revealed that miR-204-3p shares a seed sequen...

The rise of mutation-based systemic therapies for individuals with advanced thyroid cancer has underscored the significance of molecular profiling in patient care. Although next-generation sequencing (NGS) gene panels are accessible to clinicians, there is no consensus on the optimal approach to testing. This multicenter study investigates whether mutational profiling of advanced thyroid cancers can inform decisions about targeted therapies. Patients with advanced thyroid canc...

Objectives: Molecular testing of thyroid tumors is increasingly being used for the diagnosis and prognosis of patients. In some cases, however, the same gene variant may be present in both benign and malignant thyroid tissue. The issue is also a different nature (aggressiveness) of carcinomas of the same genetic origin. Comparing of DNA methylation profiles of these samples could be a possible way of distinguishing these cases. Aim of this pilot study was to analyze the DNA me...

Objectives: Chromium (Cr) is one of the major and most detrimental heavy metal pollutant. It is classified as an endocrine disrupting chemical (EDC, endocrine disruptor) and possibly thyroid disruptor. Its main forms are hexavalent (Cr(VI)) and trivalent chromium (Cr(III)). In turn, Cr is also classified as a carcinogen, with Cr(VI) belonging to group 1 of carcinogens (carcinogenic to humans) according to the International Agency for Research on Cancer (IARC) Monographs. Altho...

Objective: Molecular profile can assist differentiated thyroid cancer (DTC) treatment at a metastatic stage. We aim at describing the clinical usefulness of a circulating free DNA “liquid biopsy” (LB) analysis in terms of informative results and actionable targets identified.Methods: We analyzed all the LB results of locally advanced or metastatic DTC patients performed in a single referral center between January 2021 and January 2024. Cell fre...

Papillary thyroid cancer (PTC) has one of the highest hereditary component among malignances, which was reported in numerous epidemiological studies. The association between genetic variants (SNP- single nucleotide polymorphisms) and PTC predisposition was revealed. Still, little is known about their contribution in disease stage and an outcome.Purpose: The association of rs966423 (DIRC3), rs116909374 (MBIP), rs2439302 (NRG1) with unfavorable histopathol...