Translational thyroid cancer research-1

ea0101ps2-15-01 | Translational thyroid cancer research-1 | ETA2024

Development of a molecular quantum chemistry-based pipeline combined with publicly available datasets and robust open-source bioinformatics tools that indicate variations in redox balance genes that may have diagnostic and prognostic significance in thyroid cancer

Teixeira Elisangela , Rabi Larissa , Bufalo Natassia , Ward Laura

Thyroid cells possess a strong reduction-oxidation (REDOX) mechanism that protects DNA from oxidative stress caused by elevated reactive oxygen species resulting from the synthesis of thyroid hormones and iodides derived from the iodination of thyroglobulin. SOD1, SOD2, GPX-1, G6PD, and CYBA encode important proteins involved in REDOX reactions. Their crucial roles in the promotion and progression of various types of cancers as well as their influence on pathways frequently ac...

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ea0101ps2-15-02 | Translational thyroid cancer research-1 | ETA2024

Expression of HSA-MIR-139-5P as a clinically feasible prognostic marker for thyroid cancer

Martinez-Puente Natalia , Ruz-Caracuel Ignacio , Javier Leandro-Garcia Luis , Pian-Arias Hector , Vega-Corral Zaira , Leton Rocio , Radu Roberta , Berrizbeitia Mariolga , Mellid Sara , Reglero Clara , Eduardo Salazar-Hidalgo Milton , Arroba Ester , Diaz-Talavera Alberto , Marazuela Monica , Benito-Berlinches Amparo , Gonzalez-Garcia Irene , Campos-Mena Sandra , Dolores Lozano-Escario Maria , Guadalix Sonsoles , Calatayud Maria , Perez-Campos Ana , Lahera Marcos , Cascon Alberto , Galofre Juan C. , Curras-Freixes Maria , Caleiras Eduardo J. , Valderrabano Pablo , Robledo Mercedes , Montero-Conde Cristina

Introduction: Patients with advanced differentiated thyroid cancer are often radioiodine refractory and present worse outcome with increased mortality1. Early identification is critical for the appropriate disease management and follow-up2. In this regard, we previously found that hsa-miR-139-5p (miR139-5p) down-expression is associated with recurrent/persistent disease3. Furthermore, miR139-5p down-expression has recently been associated with ...

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ea0101ps2-15-03 | Translational thyroid cancer research-1 | ETA2024

Genomic profiling of metastases from papillary and poorly differentiated thyroid carcinomas

Da Cruz Paula Arnaud , Maximo Valdemar , Melo Miguel , Sobrinho-Simoes Manuel , Soares Paula

Objective: While the genetic repertoire of papillary thyroid carcinomas (PTCs) and poorly differentiated thyroid carcinomas (PDTCs) is well documented, there is a considerable lack of molecular profiling in the metastases of these tumors. Hence, we aim at performing a meticulous molecular profiling of metastatic PTCs and PDTCs.Methods: We retrieved and analyzed the molecular and clinical features of 136 metastatic PTCs and 33 metastatic PDTCs subjected t...

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ea0101ps2-15-04 | Translational thyroid cancer research-1 | ETA2024

Usefulness of metabolomic analyses in the pre surgical evaluation of thyroid nodules

Maino Fabio , Cantara Silvia , Mattii Elisa , Grasso Daniela , Bernini Andrea , Salvemini Antonia , Mancini Virginia , Grazia Castagna Maria

Objectives: Metabolomic is a newly emerging technology with great diagnostic potential in the oncology field. Several studies have evaluated the usefulness of the metabolomic approach in the diagnosis of differentiated thyroid carcinoma (DTC), but most of them analyzed ex vivo samples. High-field nuclear magnetic resonance (NMR), a versatile and quantitative technique, allows the analysis of complex mixtures with minimal sample preparation, identifying molecules in a wide rang...

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ea0101ps2-15-05 | Translational thyroid cancer research-1 | ETA2024

BRAF mutation is associated with tumor volume doubling time of thyroid microcarcinoma during active surveillance

Kim Jinyoung , Kyoung Lee Min , Baek Ki-Hyun

Introduction: Active surveillance (AS) is proposed as an option for the treatment of papillary thyroid microcarcinoma (PTMC), considering the indolent nature of papillary thyroid cancer. However, ongoing discussions are needed regarding the selection of target patients and long-term safety.Methods: We enrolled patients who delayed surgery for more than one year after being diagnosed with PTMC from 2014 to 2021 at a single center, and they followed until ...

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ea0101ps2-15-06 | Translational thyroid cancer research-1 | ETA2024

Methionyl-trna synthetase 1 expression as a diagnosis and prognosis factor in papillary thyroid cancer

Sung Lee Jun , Kim Seok-Mo

Background: Methionyl-tRNA Synthetase 1 (MARS1) is a critical enzyme in translation initiation, responsible for catalyzing transfer of Met to the initiator tRNA. In this study, we aimed to examine whether MARS1 expression is different between normal cells and cancer cells in thyroid tissue and if it can supplement the limitations of general cell staining methods currently performed for diagnosis of cancer.Methods: Initially, 103 patients were included in...

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ea0101ps2-15-07 | Translational thyroid cancer research-1 | ETA2024

Analysis of the impact of oncocytic cells on the performance of the thyroid molecular classifier based on micrornas and DNA: results from the optimized version of the MIR-thype test

Santos Marcos , de Oliveira Miriane , Felix de Oliveira Andrei , Nogueira Vilela Diego , Frizzo Rabelo Bruna , Mari Fredi Bruno , Fernanda Morales Augusto Isabela , Gatti Deo Thamiris , Moretto Rodrigues Bruna

Background: In thyroid nodules, the presence of oncocytic cells poses a diagnostic challenge for both cytology and molecular analysis. This challenge arises from the distinctive morphological characteristics and molecular profile of these cells, making it difficult to differentiate between benign and cancerous conditions.Objective: To evaluate the performance of the v2 algorithm version of a microRNA and DNA-based molecular classifier test (mir-THYpe ful...

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ea0101ps2-15-08 | Translational thyroid cancer research-1 | ETA2024

How (respiratory) air can complement the diagnosis of thyroid changes - a pilot study using ion mobility spectrometry

Librizzi Damiano , Bullmann Maike , Rembert Koczulla Andreas , Luster Markus , Eilsberger Friederike , Pfestroff Andreas , Bowl Wadim , Claus Franz Vogelmeier , Hooshyar Yousefi Behrooz , Boselt Tobias

The aim of this pilot study is to establish a technique that can be used to detect thyroid abnormalities at an early stage, to assess the severity of these changes and to determine whether it can be used as an adjunct to other commonly used tools such as sonography, scintigraphy, fine needle aspiration biopsy and surgery. The study included 39 subjects with no identifiable thyroid changes and 86 subjects (patients) with sonographic and/or laboratory abnormalities. In the patie...

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ea0101ps2-15-09 | Translational thyroid cancer research-1 | ETA2024

Impact of genomic biomarkers on treatment decisions and clinical outcomes in patients with radioiodine-refractory thyroid cancer and treatment with multi-tyrosine kinase inhibitors – a multi-center registry analysis

Achterfeld Josefine , Kohler Viktoria , Chirica Mihaela , Goerdts Deborah , Berg Elke , Kumbrink Joerg , Hoster Eva , Megerle Felix , Smaxwil Constantin , Sandner Benjamin , Pfob Christian H. , Zielke Andreas , Schott Matthias , Fassnacht Martin , Kroisz Matthias , Spitzweg Christine

Background: In differentiated thyroid cancer (DTC) BRAF mutations are oncogenic drivers in ~60% of cases. This mutation confers downstream MEK-ERK activation resulting in radioiodine (RAI)-refractory disease. Dedifferentiation towards poorly differentiated (PDTC) and anaplastic thyroid cancer (ATC) comes with additional mutations in TP53 or the TERT promoter. Activating alterations of RAS and RET are the most frequent alternative on...

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ea0101ps2-15-10 | Translational thyroid cancer research-1 | ETA2024

Abstract withdrawn...

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Endocrine Abstracts

46th Annual Meeting of the European Thyroid Association (ETA) 2024

Poster Presentations

Development of a molecular quantum chemistry-based pipeline combined with publicly available datasets and robust open-source bioinformatics tools that indicate variations in redox balance genes that may have diagnostic and prognostic significance in thyroid cancer

Expression of HSA-MIR-139-5P as a clinically feasible prognostic marker for thyroid cancer

Genomic profiling of metastases from papillary and poorly differentiated thyroid carcinomas

Usefulness of metabolomic analyses in the pre surgical evaluation of thyroid nodules

BRAF mutation is associated with tumor volume doubling time of thyroid microcarcinoma during active surveillance

Methionyl-trna synthetase 1 expression as a diagnosis and prognosis factor in papillary thyroid cancer

Analysis of the impact of oncocytic cells on the performance of the thyroid molecular classifier based on micrornas and DNA: results from the optimized version of the MIR-thype test

How (respiratory) air can complement the diagnosis of thyroid changes - a pilot study using ion mobility spectrometry

Impact of genomic biomarkers on treatment decisions and clinical outcomes in patients with radioiodine-refractory thyroid cancer and treatment with multi-tyrosine kinase inhibitors – a multi-center registry analysis

BiosciAbstracts