Endocrine Abstracts

Background: The effectiveness of intraoperative neuromonitoring (IONM) in reducing the risk of vocal cord palsy (VCP) after thyroidectomy is controversial. This study aimed to evaluate the impact of IONM on VCP rates, identify risk factors, and assess the trend of VCP rates over time.Methods: This retrospective observational study included consecutive patients who underwent thyroidectomy for thyroid cancer between March 2014 and June 2022. VCP rates were...

Objectives: Lenvatinib treatment significantly improves the outcome in advanced, radioiodine refractory, differentiated thyroid cancer (DTC) patients. The treatment efficacy relies on maintaining the drug dose intensity, which can be complex due to lenvatinib toxicities. Data from the SELECT study showed that interruptions for over 10% of the treatment period detrimentally affects prognosis. Nevertheless, the increasing knowledge from real-life experiences resulted in improved...

Background: The incidence of thyroid cancer is increasing worldwide. In Korea, the incidence of thyroid cancer increased from 1999 to 2011, but subsequently decreased from 2012 until recently. The most common type of thyroid cancer is papillary thyroid cancer (PTC). Although PTC has an excellent prognosis, a recurrence rate of 30% has been reported.Methods: This study retrospectively reviewed 2,842 patients who underwent primary thyroidectomy for PTC by ...

Objective: SIR may occur in, 2 - 6% of ATA low risk and 67 - 75% of high risk DTC. Regarding locoregional disease, surgery is the optimal therapeutic modality if, the smallest dimension (sd) of the targeted node is ≥ 8 or 10 mm (central or lateral compartment). In the presence of, smaller nodes, contraindications or, patient’s unwillingness for reoperation, active surveillance or minimally invasive treatments (MIT), may be considered. The purpose of this study is to...

Background: Patients with thyroid swelling, specially advanced thyroid carcinoma shows a poor prognosis, and poses challenges during surgery & with risk of more post-operative complications. For this subset of patients. Important goal is preserving quality of life.Methods: Different private hospitals & clinics and surgeons involved in thyroid surgery were involved in this survey in revealing the level of knowledge and the application of communica...

Objectives: Limited and conflicting data exist regarding mutational profiles and clinical responses to tyrosine-kinase inhibitors (TKI) in advanced radioiodine refractory thyroid cancer (RAIR-TC). The role of BRAF/RAS mutational status on progression-free survival (PFS) in patients treated with lenvatinib is controversial. This study aims to assess the impact of genetic profiles on clinical responses to lenvatinib in RAIR-TC.Materials and methods: We ana...

Introduction: Cases of locally advanced thyroid cancer can lead to spontaneous or irreversible intraoperative damage of RLN. For the correction of dysphonia with OCPS, are used static methods and the physiological reinnervation of the larynx.Methods: A prospective monocenter study of the results of 61 cases of primary larynx reinnervation in the treatment of patients with invasive forms of differentiated thyroid cancer and initial laryngeal abduction par...

Purpose: Molecularly targeted drugs are indispensable therapeutic tools for the treatment of unresectable differentiated thyroid cancer. Lenvatinib (LEN) is listed as a preferred regimen in the NCCN guidelines, and is a highly effective anti-tumor agent, but is also associated with a high rate of adverse events (AEs), which may be related to prognosis. AE management is key to LEN therapy. Although there is no recommendation in the package insert regarding the recommended time ...

Introduction: Tracheal infiltration by thyroid carcinoma causes tracheal stenoses and hemoptysis, which is often fatal. Therefore, surgical treatment of thyroid carcinoma should be performed early to ensure patency of the airway.Aim: This report deals with the diagnosis and surgical treatment of a patient undergoing resection of the trachea for recurrent thyroid medullary carcinoma infiltrating the trachea in Salah Azeize institute in March 2021.<p c...

Objectives: We aim to correlate the risk of hypocalcemia with mediastinal-recurrent cellular and lymph-node dissection, whether unilateral or bilateral, and incidental parathyroidectomy after total thyroidectomy.Material and Methods: A retrospective study was conducted over a four-year period from 2020 to 2023 in the Department of Otorhinolaryngology and Cervicofacial Surgery at Salah Azaiz Institute in Tunisia. The study included 85 patients who underwe...