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Endocrine Abstracts

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46th Annual Meeting of the European Thyroid Association (ETA) 2024

Poster Presentations

TED

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Thyroid function, feedback & disruptors

ea0101ps2-19-01 | TED | ETA2024

Analysis of thyroid stimulating immunoglobulins vs conventional TSH-receptor antibodies in clinical practice

Manousou Sofia , Mamasoula Zoi , Abdi Saran Mina , Olerod Goran , Filipsson Nystrom Helena

Objectives: Our purpose was to determine the value of thyroid stimulating immunoglobulin (TSI) in comparison to TSH receptor antibodies (TRAb) in clinical practice. The specific aims were 1) to evaluate the sensitivity and specificity of TSI, TRAb and its combination at diagnosis 2) to determine corresponding TSI cut-offs in the “Graves’ Recurrent Events After Therapy” (GREAT) score in patients with Graves’ disease (GD), and 3) to determine the predicting p...
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ea0101ps2-19-02 | TED | ETA2024

In vivo and in vitro evidence for a protective role of autoantibodies against the insulin-like growth factor-1 receptor (IGF-1R) in graves’ orbitopathy

Cosentino Giada , Lanzolla Giulia , Comi Simone , Menconi Francesca , Elisei Rossella , Santini Ferruccio , Marino Michele

The insulin-like growth factor-1 receptor (IGF-1R) is involved in the pathogenesis of Graves’ orbitopathy (GO) and a possible protective role of autoantibodies against IGF-1R (IGF-1R-Abs) has been suggested. We conducted a cross-sectional study to investigate IGF-1R-Abs serum levels in 147 consecutive patients with Graves’ disease (GD), with (n = 92) or without (n = 55) GO (primary outcome). Secondary outcomes were: 1) relationship between IGF-1R-Ab...
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ea0101ps2-19-03 | TED | ETA2024

The association of the cholesterol metabolic profile and fatty acid content with the clinical phenotype of graves’ orbitopathy

Saric Matutinovic Marija , Vladimirov Sopic Sandra , Zarkovic Milos , Ciric Jasmina , Gojkovic Tamara , Djuricic Ivana , Ignjatovic Svetlana , J. Kahaly George , Beleslin Biljana

Background: Graves’ orbitopathy (GO) is an autoimmune orbital disease of insufficiently defined pathogenesis. Hyperlipidemia has been recognized as a risk factor for GO, while statin therapy may reduce its incidence. Since statins inhibit cholesterol synthesis, a potential link between cholesterol metabolism and the ocurence of GO is possible, but still unexplored. Alongside lipid-lowering, the anti-inflammatory effects of statins may also contribute to their beneficial i...
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ea0101ps2-19-04 | TED | ETA2024

Analytical performance of a novel bioassay for blocking thyrotropin receptor antibodies

George Augustine , Lotz Johannes , Bossowski Artur , Ganz Anna-Lena , Wolf Jan , Kahaly George

Background: Blocking thyrotropin receptor (TSH-R) autoantibodies (TBAb) are present in 10-15% of patients with autoimmune thyroid disease (AITD). TBAb are functional and affect thyroid function. Analytical performance of a novel bioassay for TBAb was evaluated.Methods: Serum samples from AITD patients were tested with a CE market cell-based TBAb blocking reporter bioassay (Thyretain®, Quidelortho, USA) with expression of a Luciferase transgene as re...
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ea0101ps2-19-05 | TED | ETA2024

Lymphocytes’ immunophenotype guided treatment in a thyroid eye disease patient successfully treated with rituximab

Armenti Mirco , Muller Ilaria , Maioli Sara , Moschetti Giorgia , Rossi Giada , Crivicich Erica , Dazzi Beatrice , Montacchini Benedetta , Curro Nicola , Mantovani Giovanna , Geginat Jens , Salvi Mario

Introduction: Rituximab is an anti-CD20 monoclonal antibody used as second-line treatment for patients with moderate-to-severe and active Thyroid Eye Disease (TED) and resistant to i.v. Methylprednisolone (ivMP). Rituximab induces B-cells depletion in the peripheral blood and in target organs of patients with TED. We report on a case of a patient with active TED successfully treated with two doses of Rituximab 500 mg i.v. after immunophenotypic characterization by flow cytomet...
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ea0101ps2-19-06 | TED | ETA2024

Graves orbitopathy, does all the patients evolve in the same way?

Perini Nicolas , Santos Roberto , Romaldini Joao , Villagelin Danilo

Introduction: Graves’ orbitopathy (GO), represents the main extrathyroid manifestation of Graves’ disease, with a wide variety of clinical presentations. According to Rundle’s curve, GO is characterized by an Initial phase inflammatory phase, a severity peak followed by a stable plateau phase (fibrotic phase).Objectives: To identify and describe GO patterns distinct from the Rundle’s curve.Methods/Case Presentat...
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ea0101ps2-19-07 | TED | ETA2024

Duration of treatment for thyroid eye disease

Kozaki Ai , Inoue Rishu , Naoko Yaji , Hagimoto Ai , Nishiyama Koichi , Inoue Tosyu

Purpose: The duration of treatment thyroid eye disease (TED) varies substantially between cases, this reflects the understanding that the active phase of the condition can last from 6 to 24 months. This study considers the treatment duration for a number of common symptoms of TED.Subjects: 746 patients, 155 males and 591 females with mean age 47.7 ± 15.2 years (9-92 years), who first visited Olympia Eye Hospital in 2018 and underwent anti-inflammatory...
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ea0101ps2-19-08 | TED | ETA2024

Management of thyroid eye disease (TED) related strabismus in euthyroid patient with with negative anti thyroid antibodies

Shonia Natia , Zavrashvili Nino , Margvelashvili Natia

Introduction: The thyroid eye disease (TED) is an autoimmune disorder. Diagnosis is based on recognition of clinical features and may be supported by serologic tests of thyroid function, immune testing, and orbital imaging. Clinical orbital signs include eyelid retraction, proptosis, compressive optic neuropathy signs, eyelid erythema, chemosis, caruncular edema, and restrictive strabismus. The laboratory tests include thyroid-stimulating hormone-receptor (TSH-R) antibody, thy...
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ea0101ps2-19-09 | TED | ETA2024

A marker of inflammatory state and the clinical outcome of active go to parenteral glucocorticoids

Le Moli Rosario , Naselli Adriano , Piticchio Tommaso , Tumino Dario , Belfiore Antonino , Frasca Francesco

Oxidative stress (OX) is relevant in the pathogenesis of Graves’ ophthalmopathy (GO) an inflammatory- autoimmune disease. Hypercholesterolemia is one of the most relevant clinical conditions related to OX and it has been demonstrated to be involved in clinical presentation and activity of GO. Low density lipoproteins cholesterol (LDLc) levels evaluated before parenteral glucocorticoids (GC) administration are related to GO clinical outcome to GC. Monocyte to high-density ...
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ea0101ps2-19-10 | TED | ETA2024

Abstract withdrawn...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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