ETA2024 Poster Presentations Pregnancy (10 abstracts)
Changes of central sensitivity to thyroid hormones during pregnancy
Ioannis Ilias 1 , Charalampos Milionis 2 , Maria Alexiou 2 , Ekaterini Michou 2 , Chrysi Karavasili 2 , Evangelia Venaki 2 , Kostas Markou 3 , Irini Mamali 3 & Eftychia Koukkou 2
1Elena Venizelou Hospital, Department of Endocrinology, Diabetes & Metabolism, Athens, Greece; 2Elena Venizelou Hospital, Department of Endocrinology, Diabetes and Metabolism, Athens, Greece; 3University of Patras, Division of Endocrinology, Department of Internal Medicine, School of Health Sciences, Patras, Greece
Introduction/Aim: Central sensitivity to thyroid hormones refers to the sensitivity of the hypothalamic-pituitary-thyroid (HPT) axis to changes in circulating free thyroxine (fT4). The relationship between fT4 levels and iodine intake is complex. The aim of the present study was to assess central sensitivity to thyroid hormones in pregnancy against iodine intake.
Materials & Methods: Data were collected from 138 pregnant women (with a mean age of 29.8 years) during singleton pregnancies; women with known/diagnosed thyroid disease were excluded. Specifically, TSH and fT4 and 24-hour urinary iodine excretion (UI) were measured in each trimester. The Thyroid Feedback Quantile-based Index (TFQI) was calculated to assess central sensitivity to thyroid hormones. For the statistical analysis of TFQI by trimester, analysis of variance (ANOVA) was used, while Pearson’s correlation was used to assess TFQI vs UI.
Results: The mean TFQI index ranged from -0.08 (first trimester) to +0.23 (second trimester, p: 0.01) ending in -0.06 (third trimester), while UI was 134, 167 and 132 μg/l, respectively. The TFQI correlation was positive (Pearson r: + 0.39, p: 0.02), only for UI values between 100 μg/l - 250 μg/l, in the third trimester.
Discussion: TFQI is a new index reflecting central sensitivity to thyroid hormones. Lower TFQI indicates higher sensitivity to thyroid hormones, and in our sample this was noted in the first trimester (the critical period of organogenesis) and the third trimester (when it also appeared to be related to iodine intake). Thus, the observed changes in TFQI may reflect different ways of central action of thyroid hormones, according to the phase of pregnancy. The positive association between maternal TFQI (indicative of central sensitivity to thyroid hormone) and urine iodine levels during the third trimester may reflect the combined influence of maternal and fetal thyroid function. Our results are intriguing and have the potential to enhance our comprehension of the changes in the HPT axis’ function via variations in central sensitivity to thyroid hormones and its interplay with nutritional iodine status during pregnancy.
Volume 101
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Endocrine Abstracts
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