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Endocrine Abstracts (2024) 101 PS2-13-04 | DOI: 10.1530/endoabs.101.PS2-13-04

Salah Azaiez Institute, Ent, Carcinologic Head & Neck Surgery, Tunisia


Purpose: To Study the clinical, paraclinical and therapeutic features of medullary thyroid carcinomas (MTCs)

Methods: Retrospective study of 17 patients treated for MTC over a period of 6 years [2016-2022]

Results: The mean age was 52.6 years and Sex-ratio was 0.88. Clinically, the thyroid nodule was hard (5cases) fixed (2cases) associated with adenopathy in 6 cases and recurrent paralysis in 4 cases. Ultrasound showed nodules classified Eutirads 5 (12cases) and Eutirads 4 (5cases). The mean value of calcitonin was 1061 pg/ml. Five patients had distant bone metastasis, pulmonary metastasis in 2 cases and hepatic metastasis in 2 cases. Total thyroidectomy was performed in 15 cases associated with central lymph-nodes dissection in 12 cases and lateral lymph-nodes dissection in 8 cases. A radical lymph-nodes dissection was necessary in 2 cases. A tracheal resection and anastomosis were performed in one patient. For two patients, only a thyroid biopsy was performed. On final histology exam, multifocality was found in 4 cases. The average tumor size was 2.96 cm. Lymph-node involvement was found in 6 cases. Postoperative radiotherapy was performed in 8 cases. After a mean follow-up of 2.4 years, five patients presented a metastatic recurrence. Three patients received targeted therapy.

Conclusion: MTC is a rare neuroendocrine tumor. The increasing knowledge about diagnostic and therapeutic strategies has been leading to better prognosis.

Volume 101

46th Annual Meeting of the European Thyroid Association (ETA) 2024

European Thyroid Association 

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