Endocrine Abstracts

Introduction: Medullary thyroid carcinoma (MTC) is a rare malignant tumor that originates from the thyroid C cells. MTC may occur sporadically (75%) or as part of cancer syndrome (hMTC). hMTC is associated with germline mutations in the RET proto-oncogene. The pathogenic variants at codon 634 were the most prevalent (30-50%). Other pathogenic variants were found in less than 10% of MEN2A subjects. The rare RET variant p. Ser904Phe has been reported in only 3 kindreds worldwide...

Background: Calcitonin (CTN) is the main marker for the diagnosis and follow-up of patients with MTC. Its value, either basal (bCTN) or stimulated (sCTN) after calcium stimulation test (Ca-Test) is used in clinical practice for the diagnosis of patients with suspicious MTC. The aim of our study is to evaluate the performance of bCTN and sCTN in patients undergoing surgery with suspicion of sporadic MTC.Methods: We evaluated 158 consecutive patients (Jan ...

Introduction: Calcitonin (Ct) is the most sensitive serological marker of medullary thyroid carcinoma (MTC). Its assay however is plagued by numerous interferences with consequent high risk of false diagnoses and unnecessary thyroidectomy. Numerous studies have been conducted to identify potential alternative MTC serum markers, among which the most promising one is procalcitonin (proCt). This work aims to present the possible use of proCt in unmasking cases of false hypercalci...

Purpose: To Study the clinical, paraclinical and therapeutic features of medullary thyroid carcinomas (MTCs)Methods: Retrospective study of 17 patients treated for MTC over a period of 6 years [2016-2022]Results: The mean age was 52.6 years and Sex-ratio was 0.88. Clinically, the thyroid nodule was hard (5cases) fixed (2cases) associated with adenopathy in 6 cases and recurrent paralysis in 4 cases. Ultrasound showed nodules classi...

Objectives: Distant metastases (DM) and/or biochemical persistent disease (BPD) in MTC, adversely affect disease prognosis. Calcitonin and CEA doubling-times (DTs) are the main prognostic indicators for disease progression. Liquid biopsy based on CTCs enrichment and characterization seems to be an intriguing non-invasive tool providing information about tumor biology and molecular identity. The aim of this study was the molecular characterization of CTCs in spMTC patients with...

Objectives: There is still controversy in different guidelines regarding the necessity of routine preoperative calcitonin (Ctn) testing in medullary thyroid cancer (MTC). The impact of Ctn screening on surgical decision and clinical outcomes remains debated.Methods: This retrospective multicenter-cohort study involved 149 MTC patients from 6 centers between 2013 to 2023. Clinical characteristics, surgical procedure and clinical outcomes were compared bet...

Background: Medullary thyroid carcinoma (MTC) is a malignant tumor originating from C-cells producing calcitonin (CTN). Most of the MTC are sporadic and can potentially metastasize to lymph nodes and distant sites. High pre-operative CTN values and larger tumor dimension are usually associated with metastatic disease. However, anecdotal cases of large sporadic MTC with high pre-operative CTN values, without lymph nodes metastases, and completely cured after surgery have been d...

Introduction: Medullary thyroid carcinoma (MTC) is a rare neuroendocrine tumor that originates from the parafollicular thyroid cells (C cells); MTC occurs as both a hereditary disease (25% of all cases), when MTC in a manifestation of multiple endocrine neoplasia type 2 or 3 (MEN 2/3) and as sporadic disease. The hereditary type is a consequence of germline mutation in the rearranged during transfection (RET) proto-oncogene, which can undergo oncogenic activation through both ...

Objectives: Medullary thyroid carcinoma (MTC) is a rare neoplasm that occurs in sporadic (75%) (sMTC) or familial (25%) (fMTC) form, the latter caused by germinal mutations of the RET gene. In fMTC, cases can be distinguished into index cases, the first case who were diagnosed in a specific family, then apparently sporadic at the time of surgery, and gene carriers identified through RET screening starting from the index case. The aim of this study was to eval...

Background: Medullary thyroid carcinoma (MTC) has a high predisposition to neck lymph node involvement, which correlates with worse outcome. Peritumoral stromal desmoplasia, defined as the presence of a newly formed stroma surrounding tumor cells, is a strong predictor of lymph node metastases in MTC.Objective: The main purpose of the present study is to characterize peritumoral stromal desmoplasia in MTC, through the identification of other associated h...