ETA2024 Poster Presentations Diagnosis of thyroid cancer-2 (11 abstracts)
The value of acr, european, korean and ATA ultrasound risk stratification systems combined with ras mutations for detecting thyroid carcinoma in cytologically indeterminate and suspicious for malignancy thyroid nodules
Lorenzo Scappaticcio 1 , Nicole Di Martino 2 , Pamela Ferrazzano 3 , Pierpaolo Trimboli 4 , Maria Ida Maiorino 3 , Katherine Esposito 3 & Giuseppe Bellastella 3
1University OF Campania Vanvitelli, University OF Campania Vanvitelli, Naples, Italy; 2University of Campania Vanvitelli, Italy; 3Aou University of Campania "Luigi Vanvitelli", Italy; 4Thyroid Center, Oncology Institute of Southern Switzerland, Lugano, Switzerland
Objectives: The aim of this study was to evaluate the diagnostic value of four commonly utilized ultrasound (US) RSSs (the American College of Radiology [ACR], European [EU], Korean [K] TI-RADSs and American Thyroid Association [ATA] US-based RSS criteria) in combination with activating point mutations of the RAS genes (NRAS, HRAS, and KRAS) for detecting thyroid carcinoma in cytologically indeterminate and suspicious for malignancy thyroid nodules.
Methods: We retrospectively analyzed cytologically “indeterminate” and “suspicious for malignancy” thyroid nodules which underwent US, molecular testing and surgery between September 1, 2018, and December 31, 2023. Receiver operating characteristic (ROC) curves were generated, and the area under the curve (AUC, 95% confidence interval [CI]) was calculated.
Results: 100 cytologically “indeterminate” and 24 “suspicious for malignancy” thyroid nodules were analyzed. Compared to the four US-based RSSs alone, diagnostic value of the four US-based RSSs combined with RAS mutations did not significantly improved (cytologically “indeterminate”, AUC [95% CI] 0.6 [0.5-0.7] and 0.6 [0.5-0.7], respectively, p = 0.70; cytologically “suspicious for malignancy”, AUC [95% CI] 0.7 [0.5-0.9] and 0.8 [0.6-0.9], respectively, p = 0.23).
Conclusions: Diagnostic value of the main four US-based RSSs (ACR, EU, K, ATA) was not improved in conjunction with the evaluation of RAS mutations for preoperative risk stratification of cytologically indeterminate thyroid nodules.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more