ETA2024 Poster Presentations Clinical thyroid cancer research-2 (10 abstracts)
High concordance in intuitive vs standardized assessment of whole-body scintigraphy after radioiodine therapy for thyroid cancer
Friederike Eilsberger 1 , Hannah Wolfram 1 , Kathrin Pfestroff 1 , Damiano Librizzi 1 , Markus Luster 2 , Jan Taprogge 3 & Andreas Pfestroff 1
1University Hospital Marburg, Nuclear Medicine, Marburg, Germany; 2University Hospital Marburg, University Hospital Marburg, Department of Nuclear Medicine, Marburg, Germany; 3The Royal Marsden, Nuclear Medicine, London, United Kingdom
Objective: In patients with differentiated thyroid carcinoma, whole-body scans (WBS) are usually assessed 48 h after radioiodine administration. The aim of the study is to correlate the intuitive assessability after different time points with the standardized diagnostic algorithm.
Methods: Data were available from 35 consecutive, prospectively treated (97% exogenous TSH stimulation) patients in whom WBS were acquired at up to 6 time points (6, 24, 48, 72, 98 and 168 h). Blinded reading of WBS was done by to three experienced observers regarding diagnostic quality. After one year of latency, the whole-body scintigraphies were re-evaluated using a standardized Likert scale (Van Nostrand criteria). The qualitative ranking was determined intuitively, the standardized quality was determined using a predefined scale (1 to 5 points) for 10 parameters (max. 50 points).
Results: The intuitive ranking of the three observers was consistent in terms of the best scan after 24 h (average rank 1.76), followed by 48 h (rank 2.27), 6 h (rank 2.77) and 72 h (rank 3.48); only the last two scans after 96 and 168 h were discordantly ranked 5th (rank 4.55) and 6th (rank 4.58) respectively. After using the standardized evaluation criteria, all observers had the same ranking, only one observer rated 4 and 48 h scans on average as equivalent (31.66 vs. 31.32 points).
Conclusions: There was a high concordance in the intuitive vs standardized assessment of the diagnostic value of the whole-body scans and between the investigatores. The diagnostic performance of the scans after 24 h (rank 1; 39.52 points) is comparable to that after 48 h (rank 2; 34.73 points); for radiation protection reasons, a preference for the 48 h scan is advisable.
Volume 101
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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