Endocrine Abstracts

Introduction: Insulin resistance and diabetes have been lined to increased tumorigenesis and tumor aggressiveness in a multitude of cancers, but that link seems controversial when it comes to thyroid cancer. The present work aims to characterize the effects of various forms of diabetes [autoimmune = type 1 + LADA = DM1 vs. type 2 diabetes = DM2] on the incidence and features of tumor aggressiveness of thyroid cancers in comparison to the general population (non-diabetes = non-...

Backgroud: Thyroid cancer, particularly papillary thyroid carcinoma (PTC), is globally on the rise, driven by increased incidental findings. PTC treatment boasts a commendable 93% 10-year survival rate, yet up to 28% of patients experience locoregional recurrences. Serum thyroglobulin (Tg) serves as a vital marker in post-operative surveillance for differentiated thyroid cancer (DTC). Anti-thyroglobulin antibodies (TgAb) play a crucial role in Tg interpretation, with their int...

Objectives: To analyze acute and late toxicities and long-term quality of life (QoL) in patients who underwent locoregional external beam radiotherapy (EBRT) for thyroid cancer and to assess the correlation of QoL with treatment characteristics.Methods: Patients treated with locoregional EBRT for thyroid cancer at University Medical Centre Groningen (UMCG) (2007-2023) were included. Patient/treatment characteristics were extracted from patient files retr...

Objectives: Thyroid cancer is the common occurring cancer in women of reproductive age. The impact of thyroidectomy on childbearing plans remains unknown. The aim of this study is to longitudinally compare the reproductive concern and intention between young female patients with differentiated thyroid cancer (DTC) and those with thyroid benign disease after thyroidectomy.Methods: This prospective cohort study enrolled female patients with DTC or thyroid ...

Background: The impact of lymph node metastases (LNM) on the outcome of patients with DTC has been reevaluated in the last years. Its relevance is linked not only to the absence/presence of LNM, but also to other features such as number of LNM, dimension and extranodal extension (ENE).Aim: The aim of this study was to evaluate in a large series of patients with DTC the impact of LNM on the clinical outcome. Patients were divided according to the risk of ...

Background: Thyroglobulin (Tg) plays a crucial role in managing patients with differentiated thyroid cancer (DTC). The utility of Tg in early and long-term follow-up of DTC patients has been well-documented. Although third-generation Tg immunoassays have improved accuracy, limitations persist, such as interference from antithyroglobulin antibodies and variability in measurements. Changes in DTC treatment approaches necessitate reevaluation of Tg thresholds. This study aims to ...

Objectives: In clinical trials assessing efficacy and safety of the highly selective RET inhibitor selpercatinib (Libretto-001 and 531), hypothyroidism was often described. We aimed to evaluate the variation of thyroid function tests (TFTs) in patients with advanced progressive medullary thyroid carcinoma (MTC) treated with selpercatinib at the Unit of Endocrinology of Pisa University Hospital.Methods: We evaluated clinical and biochemical data of 19 thy...

Introduction: Pediatric differentiated thyroid carcinoma (DTC) is a rare disease. In the literature, there are limited data for this type of tumor; in particular, it has never been evaluated the efficacy of radioiodine treatment with 131-I after 4-6 weeks from thyroid hormone withdrawal (THW) compared to the use of recombinant TSH (rhTSH); for this reason, the decision is often left to the experience of the team.Aim: To compare the efficacy and safety of...

Background: The effect of L-thyroxine therapy on bone mineral density (BMD) in patients with differentiated thyroid carcinoma (DTC) is still controversial.Objectives: The aim of this preliminary investigation was to evaluate the role of the evaluation of trabecular bone score (TBS) and body composition in addition to the BMD in a cohort of DTC patients.Methods: The study involved a total of 104 patients who underwent total thyroide...

Introduction: Differentiated thyroid cancer (DTC) has low recurrence rates (2-5%). Despite this, the CDT consensus recommends long-term follow-up with specialists without defining a maximum follow-up time. Telemedicine is a strategy that aims to optimize the transition of care for patients from tertiary care to primary health care (PHC) and can help in the follow-up of these patients.Objective: To evaluate the impact of the transition of care between spe...