Endocrine Abstracts

Background: Osseous metaplasia (OM) of the thyroid parenchyma and intrathyroidal mature bone formation present rare findings in the pathological evaluation of resected thyroid specimens. Graves’ disease is the most common cause of hyperthyroidism and thyrotoxicosis, is mostly characterized by diffuse enlargement of the thyroid gland and occasionally features nodular lesions with a variable percentage of malignant transformation. Herein, we present the case of a female pat...

Introduction: Levothyroxine monotherapy is the standard treatment for hypothyroidism; it is safe and inexpensive, restores thyroid function tests to within the reference range, and improves symptoms in most patients. However, some patients require Liothyronine (LT3) to improve symptoms, and there is less safety data available for this. Here we report a case of sudden death in a patient using Liothyronine and present a safety data review for Liothyronine and Levothyroxine using...

Introduction: Methimazole is an antithyroid medication which is now considered the first line agent for medical therapy of Graves’ disease. Rare complications of methimazole (<1%) include agranulocytosis, aplastic anemia, nephritis and hepatitis. We would like to report the rare case of the patient with Methimazole-induced hepatitis.Case Presentation: A 46-year-old woman, who complained of fatigue, loss of appetite, nausea, vomiting, jaundice, d...

Introduction: Immune checkpoint inhibitors are used as therapy for advanced malignancies. The therapy is based on immune enhancement, thus, autoimmune side effects referred to as immune-related adverse events may occur. Thyroid function abnormalities have been reported, but more evidence is needed to substantiate the main subtypes and course of thyroid disease associated with this treatment.Case report: A 51-year-old woman with metastatic pancreatic canc...

We present the case of a 22-year-old male patient who posed a diagnostic dilemma due to discrepancies between his symptoms and biochemical markers in contrast to imaging findings. He reported a 18 month history of on and off neck swelling with associated symptoms of anxiety, tremor, loose stools and dry eyes (no weight loss). Thyroid function tests were normal with a Free T4 (FT4) of 12.4 pmol/l (12-22 pmol/l), TSH 2.75mU/l (0.27-4.2mU/l) and an ultrasound showed an enlarged a...

Introduction: Graves orbitopathy (GO) is the most common extrathyroidal manifestation of autoimmune hyperthyroidism, although it can rarely occur in euthyroid and hypothyroid patients with chronic autoimmune thyroiditis. The eye involvement in GO is frequently bilateral and symmetric. When atypical ocular or incongruent biochemical findings occur, conditions that may mimic GO should be excluded. Immunoglobulin G4 - related disease (IgG4-RD) is a rare, progressive immune-mediat...

A 58-year-old woman presented left eye twitching, diplopia. irritation and conjunctival and periorbital edema, also left exophthalmos. Her medical history revealed a recent diagnosis of Hashimoto thyroiditis and hypothyroidism, for which she had been prescribed levothyroxine 50 mg daily for one month. Patient present test result, which she made 1 month ago.TSH- 8,4266Uu/ml (0,350-5,500)<p cl...

Ectopic Graves’ disease and sustained thyrotoxicosis after total thyroidectomy are extremely rare. In this abstract, we report a case of a 34-year-old female, presenting at our department for persistent Graves’ disease (GD) despite total thyroidectomy performed at an affiliated hospital 4 months earlier and cessation of thyroid hormone replacement 6 weeks before presentation. She complained of palpitations, nervousness and sweating. Her pulse rate was 82/min, while o...

Introduction: Thyrotoxic periodic paralysis (TPP) is characterized by muscle paralysis, hypokalemia and thyrotoxicosis. Mutations occurring in the genes that encode for ion channels (CACNA1S and KCNJ18) are thought to be involved in its onset. TPP mainly affects male subjects (M:F=26:1), Asian (2% of Asian subjects with thyrotoxic suffer from TTP), while it is rare in Caucasian population (0.1-0.2% of thyrotoxic subjects). Signs and symptoms of thyrotoxicosis are often absent ...