Endocrine Abstracts

Objective: The first orphan nuclear receptors discovered were Estrogen Related Receptors (ERRs), which were recognized due to their sequence closeness to the classical estrogen receptors. Countless impartial studies have linked ERRγ to the onset and progression of several malignancies, including thyroid cancer. Moreover, it is recognized that ERRγ has a unique function in controlling metabolic effectors, cell cycle progression, and apoptosis in cancers of different k...

Introduction: Thyroid gland fibrosarcomas are very rare tumors, with only very few cases have been reported in the literature. Their similarity to anaplastic thyroid cancer poses a diagnostic challenge, often leading to misdiagnosis.Case Report: We report the case of an 87-year-old female with a history of left thyroid nodule who underwent a left lobectomy and subsequently received levothyroxine therapy. She presented with a rapidly growing mass on the r...

Background: Recently, immune checkpoint inhibitors (ICI) have been applied for the anaplastic thyroid cancer, and the need is increasing to optimize this treatment. The aim of this study is to investigate whether low dose radiotherapy can enhance the therapeutic efficacy of immune checkpoint inhibitor in a mouse anaplastic thyroid cancer model.Methods: Mouse anaplastic thyroid cancer cell line TBP-3743 was implanted subcutaneously in C57BL/6 mouse. Mice ...

Introduction: Aggressive forms of papillary thyroid carcinoma are more commonly observed; anaplastic and poorly differentiated types are rarer, but have a higher death rate. The transformation from papillary to anaplastic is a rare occurrence; it is even more uncommon for a small region of well-differentiated thyroid cancer to occur alongside the anaplastic form in metastatic lymph nodes.Aim: We present a case of an aggressive form of papillary thyroid c...

Aim: To study the clinical, evolutive and therapeutic features of anaplastic thyroid carcinoma.Methods: Retrospective descriptive study of twenty patients managed for anaplastic thyroid carcinoma over a twenty-one-year period from January 2003 to December 2023.Results: The mean age of our patients was 60 years. The average consultation time was 41.5 months, with extremes ranging from two months to 20 years. Eighteen patients consul...

Objective: NF1 alterations may be present in about 3% of Anaplastic thyroid cancers (ATC) in alternative to classic driver mutations; moreover, NF1 is included in several trials as target for therapy with MEK inhibitors. The objective of this study is to better characterize the role of NF1 in ATC.Methods: For this purpose, DNA and RNA were extracted from 32 cases of ATC/PDTC. We firstly analyzed classic driver mutations with 2 Next-Generation Sequencing ...

Anaplastic thyroid cancer (ATC) is highly aggressive, and the clinical treatment and management is still challenging. In-depth knowledge of the pathways involved in the phases of tumour initiation and progression of ATC has shifted attention on the use of targeted and personalized therapies, that are based on the tumour’s genetic profile. In this context, in vitro studies allow a good preclinical evaluation of the antineoplastic effect of the drugs. We aimed to t...

BackgroundBRAF/MEK inhibitors (BRAF/MEKi) dabrafenib + trametinib have revolutionized the treatment of BRAFm-ATC, but response is often short-lived. We previously reported that addition of an anti-PD-1 immune checkpoint inhibitor (ICI) to BRAF/MEKi prolongs overall survival (OS). Yet, some patients still develop resistance and progress. In BRAF V600E-mutated melanoma, OS is longer when BRAFi is continued beyond disease progression. Lenvatinib + pembrolizuma...

Introduction: ATC is the most aggressive thyroid cancer with a median overall survival of 6-12 months. The early detection of targetable molecular alterations (MAs) and matched targeted therapies might improve the prognosis.Objectives: To evaluate the clinical applicability of liquid biopsy (LB) for the molecular profiling of ATCs.Methods: This monocentric study retrospectively analysed consecutive ATC patients seen from January 20...

Introduction: Current imaging modalities for anaplastic thyroid cancer (ATC) have limited efficacy in evaluating remission and predicting recurrence due to residual disease. Circulating tumour DNA (ctDNA), isolated from liquid biopsies, could complement these methods and enhance diagnostic follow-up and disease monitoring. However, clinical follow-up studies using ctDNA in ATC remain scarce.Case report : An eighty-one-year-old woman with a history of HER...