Endocrine Abstracts

Objective: Thyroid function tests are common biochemical analyses and agreement between the routinely used immunoassays is important for diagnosis and monitoring of thyroid disease. Efforts are continuously made to align the biochemical assays, and we aimed to evaluate agreement between immunoassays used in a clinical laboratory setting among non-pregnant and pregnant adults. Methods: We performed a cross-sectional study including serum samples from 192 ...

Objective: TSH-receptor antibodies (TRAb) are key markers to distinguish Graves’ disease from gestational hyperthyroidism in pregnancy in clinical practice. We aimed to measure stimulating TRAb (TSI) using the Turbo TSI bioassay for establishment of early pregnancy cut-off and comparison with immunoassay measurements of TRAb.Methods: We performed a retrospective cohort study within the North Denmark Region Pregnancy Cohort (2011-2015) and identified...

Background: Thyroid hormone is an important regulator of fetal brain development. Low and high maternal free thyroxine concentrations during pregnancy have been associated with less grey matter and cortex volume. However, it remains unknown whether certain areas of the brain are differently affected. We used state-of-the-art brain MRI analyses in the largest mother-offspring imaging cohort worldwide to further elucidate how maternal thyroid function during early pregnancy affe...

Background: Congenital hypothyroidism (CH) is the most frequent cause of preventable cognitive deficit. With newborn screening program, natural history of this disease has changed thanks to the precocious treatment with levothyroxine (LT4). In a previous study we evaluated psychosocial outcome and quality of life of 62 adults with primary CH diagnosed in the screening era, finding only small differences from controls in concentration ability and mood, while social and work ada...

Objective: A link between levels of maternal thyroid hormones in pregnancy and the biochemical markers of placental dysfunction, soluble fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PlGF), has been brought forward. Sparse evidence is available on the dynamics of sFlt-1 and PlGF in early pregnancy and the association with maternal thyroid function in early pregnant women specifically.Methods: A retrospective cohort study within the Nor...