Endocrine Abstracts

Objective: Graves’ disease (GD) exhibits a higher prevalence in females compared to males. Sex hormones might influence susceptibility of this disease. Studies have shown that 5α-dihydrotestosterone (DHT) treatment can provide protection against GD. In order to further confirm the protective effect of different forms of androgen against GD and its preventive mechanism, the current investigation was designed to explore gender difference and response to testosterone or...

Objectives: Drug-induced acute liver failure (ALF) is a rare but life-threatening clinical scenario which occurs in individuals without pre-existing liver disease. Intoxication of the pain-reliever acetaminophen (APAP) is a well-known trigger for ALF. The cytochrome P450 enzyme CYP2E1 converts APAP to the toxic metabolite N -acetyl- p -benzoquinone imine (NAPQI) which is inactivated by endogenous glutathione. If glutathione is depleted, NAPQI triggers hepatoc...

Objectives: Differentiation of orbital fibroblasts (OFs) into myofibroblastic phenotype contributes to tissue remodelling in thyroid eye disease (TED). Our study aimed to investigate the impact of TGF-β1 induced myofibroblast differentiation on hyaluronan turnover, with a particular focus on the expression of its key enzymes.Methods: OF cultures were established from tissue samples acquired from decompression surgeries of patients with TED (TED-OFs;...

Objectives: Cholesterol gallstone disease has a prevalence of 10-15% being one of the most common gastrointestinal pathologies. It is well known that thyroid hormone (TH) impacts the hepatobiliary system. Epidemiological studies suggest a link between thyroid dysfunction and cholestatic liver disease. In our previous studies we could confirm that a severe systemic TH deficiency promotes cholesterol gallstone formation in C57BL/6 mice. Using the lithogenic mouse model, in the p...

Background: Constitutively active thyrotropin receptor (TSHR) mutations are the primary cause of non-autoimmune hyperthyroidism (NAH). The TSHR is a key regulator of thyroid function, which, through thyroid hormones, plays a crucial role in bone formation and resorption. Beyond influencing skeletal bone growth, thyroid hormones also regulate craniofacial development. Furthermore, in addition to thyroid hormones an independent role of TSH on bone development has been proposed. ...