Endocrine Abstracts

Introduction: Our previous observations suggested that high titers TPO antibodies titers limit the extent of differentiated thyroid cancer.1 Other studies found an opposite effect, especially when it comes to indolent tumors. We designed the present study to assess whether TPO antibodies have differential effects on the expansion/progression of aggressive (AGG) as opposed to non-aggressive (NAG) tumors of follicular cells origin (TCFO).Methods...

Objectives: In the personalized medicine era, application of multi-gene Next Generation Sequencing (NGS) panels may be used to analyze plasma circulating tumoral DNA (ctDNA) obtained by liquid biopsies of tumor patients improving management of patients undergoing targeted therapy. This analysis may identify genetic alterations responsible for response and/or resistance during target therapy and may be useful in identifying other biomarkers. Aim of this study was to evaluate th...

Objective: Patients with non-medullary thyroid carcinoma (NMTC) that are refractory to radioactive iodine (RAI) have a bad prognosis. For these patients, treatment options are limited. RAI refractoriness is the result of reduced RAI uptake by NMTC cells, caused by loss of function of the Na/I symporter. Strategies for restoring the ability of NMTC cells to take up RAI, so called “redifferentiation”, are promising treatment modalities. Preclinical studies have shown t...

Introduction: Paediatric thyroid cancer (TC) is characterised by higher aggressiveness and recurrence rates compared to adult TC. The risk stratification system for paediatric TC is simplified relative to that of adults. Paediatric tumours mostly harbour gene fusions, while adult TC frequently present oncogenic point mutations. Yet, 40-50% of genomic alterations driving tumourigenesis and conferring aggressiveness to radiation-unrelated paediatric papillary TC (PTC) remain unk...

Introduction: active surveillance (AS) is feasible and safe for low-risk papillary thyroid carcinoma with diameter ≤ 1.3 cm (mPTC), as this type of cancer shows a low percentage of progression. At the present time, there are no prognostic factors which could help to identify mPTCs at higher risk of progression. The aim of this prospective study is to find a specific molecular signature of cases that showed disease progression during AS and which would allow their early i...

Background: Despite the use of aggressive, multimodal therapy (surgery + radiation therapy + systemic therapy), management of advanced thyroid cancers such as anaplastic thyroid cancer (ATC) remains a major challenge. Identifying predictive biomarkers of treatment response are primordial to improving overall survival for patients with ATC. Gut microbiota have been linked to both treatment response and levels of adverse effects to treatment in cancers such as melanoma or colore...

Background: Thyroid nodules are present in nearly 60% of the population, representing the most frequent endocrine disease. Fine-needle aspiration (FNA) cytopathology classifies 20%–30% of nodules as indeterminate (Bethesda 3 and 4), a scenario in which molecular tests are recommended aiming to avoid unnecessary diagnostic surgeries.Objective: The aim was to evaluate the diagnostic performance of the new v2 algorithm of mir-THYpe full molecular class...