Endocrine Abstracts

Objective: Point-of-care (POC) technologies, where the sample collection and biomarker measurement are undertaken immediately can reduce turnaround times for such measurements to a period of minutes and facilitate prompt diagnosis of e.g. thyroid dysfunction. This streamlined process is especially useful in the primary care setting, and in resource-poor environments such as developing countries, where recalling patients to receive their diagnosis can be challenging. To realize...

Serum levels of TSH in euthyroid individuals are frequently associated with favorable outcomes. However, whether this association is merely an epiphenomenon of longevity or whether TSH may correlate with a metabolic protective profile is unclear. We investigated the putative association between TSH serum levels and cardiovascular outcomes in euthyroid participants. We hypothesized that participants with higher TSH might present a protective cardiovascular clinical profile. We ...

Objective: decreased survival and higher cardiovascular risk have been reported in a UK cohort of RTHβ patients, but there is no evidence from other countries.Methods: retrospective study of an Italian cohort of RTHβ patients, carrying heterozygous pathogenic variants in the THRB gene and diagnosed in the period between 1984 and 2023. We collected records at diagnosis of 284 cases, whereas longitudinal data were available in 249 RTH&#9...

Objectives: Quality of life (QoL) is reduced in treated hyperthyroidism compared to age- and sex-matched controls. We previously reported excessive weight regain with the treatment of hyperthyroidism. Whether the treatment-related weight gain is affecting QoL of this patient group is unknown.Methods: With a cross-sectional study design and data utilization from a prospectively completed database, we enrolled patients with treated hyperthyroidism. We incl...

Background: Monocarboxyate transporter 8 (MCT8) deficiency is a rare neurodevelopmental and metabolic disorder caused by mutations in the thyroid hormone transporter MCT8. The Triac Trial I and subsequent real-world data showed that T3 analogue Triac safely normalizes serum T3 concentrations and ameliorates symptoms of peripheral thyrotoxicosis in paediatric and adult patients.Objective: To study the effect of Triac on patient-centered outcome measures i...

Objectives: Hyperthyroidism affects up to 3% of the population and is associated with arrhythmias, which predispose to myocardial infarction, stroke and pulmonary embolism. Multiple studies indicate that all-cause and cardiovascular mortality are higher in patients with hyperthyroidism compared to the general population. However, associations between treatment modalities for hyperthyroidism and long-term health outcomes remain unclear. This study aims to analyse the literature...

Objective: LT4/LT3 combination treatment for persistent hypothyroid symptoms is increasingly used and requested by patients, but the efficacy and side effects of long-term therapy remain largely unexplored. This study aimed to describe the patient group experiencing a long-lasting effect of LT4/LT3 and to evaluate the impact on Quality of life (QoL) and hypothyroid symptoms.Method: In this cross-sectional study, we invited 147 patients. We included 66 pa...