Endocrine Abstracts

Introduction: The 2022 WHO Classification categorizes oncocytic (OTC) and follicular thyroid carcinoma (FTC) based on the degree of capsular and vascular invasion into minimally invasive (MI), encapsulated angioinvasive (EA) and widely invasive tumors (WI). While associations with clinical outcomes have extensively been studied in FTC, for OTC robust clinical data is lacking. The aim of this study is to investigate the newly defined categorization by the 2022 WHO Classificatio...

Background: Tyrosine kinase inhibitors (TKIs) have been shown to improve progression-free survival (PFS) in advanced thyroid cancer (TC), though their administration is burdened by multiple adverse events (AEs). Maintaining optimal drug dosage for optimal tumour response can be challenging and prehabilitation, aiming to improve patient well-being before cancer treatment, is becoming relevant in this context. While some information exists for other cancers, no data are availabl...

Introduction: Treatment of Graves’ Orbitopathy (GO) remains a challenge. Approximately 20-30% of patients show resistance or incomplete response to high-dose glucocorticoid therapy. According to current guidelines the use of tocilizumab (TCZ), a monoclonal antibody against IL6 receptor, has been proposed as one of the second-line therapies.Objectives: Our aim was to assess the efficacy and safety of TCZ treatment in patients with glucocorticoid-resi...

Objectives: MCT8 deficiency results from a rare X-linked genetic defect in the thyroid hormone monocarboxylate transporter (MCT) 8. MCT8 deficiency is characterized by severe neurocognitive disabilities and peripheral thyrotoxicosis. Mortality rates in MCT8 deficiency are high with 30% dying during childhood. The T3 analogue triiodothyroacetic acid (Triac) has been proven to safely alleviate peripheral thyrotoxicosis in patients with MCT8 deficiency. As thyrotoxicosis is linke...

Objective: The clinical course of metastatic lymph nodes in patients with differentiated thyroid cancer is unclear, due to the lack of universal criteria defining disease progression. The aim of the present study was to evaluate the characteristics of suspicious lymph nodes in patients with differentiated thyroid cancer, in order to distinguish lesions with an indolent behaviour and to identify potential predictors of disease progression.Methods: We retr...

Background: Maternal thyroid hormones regulate neurodevelopment of the fetus. Maternal thyroid dysfunction has been associated with lower offspring IQ and alterations in brain morphology in early childhood, but it remains unknown if these associations persist as development progresses.Methods: We performed a prospective cohort study including participants from an ongoing birth cohort in Rotterdam, the Netherlands, with data on gestational thyroid functio...