Endocrine Abstracts

Thyroid hormone receptor a1 (TRa1) mediates the genomic action of thyroid hormone (T3). The biology of TRa1 in growth, differentiation, and development is well studied, but how TRa1 could crosstalk with key regulators involved in cancer development is largely unknown. In the present study, we used an epithelial cell line (NCM460D, referred to as 460D hereafter), established from normal human colon mucosal epithelium as a model to explore the interaction of TRa1 with the tumor ...

Kelch-like protein 14 (KLHL14) is a member of the Kelch protein family acting as a subunit of E3-ubiquitin ligase. KLHL14 and its antisense lncRNA, KLHL14-AS, are among the most enriched transcripts in the developing mouse thyroid. Recently, we showed that KLHL14-AS is a tumor suppressor in thyroid carcinomas (TC) involved in the maintenance of differentiation and proliferation rate of thyroid follicular cells. KLHL14 is a tumor suppressor in Diffuse Large B Cell Lymphoma, its...

Background: Resistance to thyroid hormone (TH) beta (RTHβ), caused by mutations in the THRB gene, is characterized by elevated serum (F)T4 accompanied by non-suppressed TSH concentrations. Disease features arise from variable resistance to TH action in tissues expressing Thyroid Hormone Receptor (TR) β and from thyrotoxic effects in tissues expressing TRα1, most notably the heart. A recent clinical study showed a 3-times higher risk of cardiovascular mo...

Background and objectives: Recent studies have identified pleiotropic roles for the Nrf2 antioxidant response in the physiology of the thyroid gland and in the pathophysiology of various thyroid diseases. Various natural compounds have antioxidant properties and/or thyroidal effects, but it is not well known whether and how the two are related. The aim of the present study was to characterize in a systematic manner the thyroidal and antioxidant effects of natural compounds.</p...

Obesity incidence is continuously increasing worldwide. It does not solely result from excess calorie intake and sedentary lifestyle. Environmental endocrine disrupting chemicals (EDCs), could also be involved, deregulating fat storage and energy balance. Thyroid hormones (THs) play major role for maintaining energy balance. They are well known to control all aspects of metabolism, acting both centrally and in peripheral metabolic organs to control lipid and carbohydrate metab...

Autoimmune hypothyroidism, also known as Hashimoto’s thyroiditis (HT), is a common autoimmune thyroid disorder with a prevalence of 3-5% in the United States and Europe. Despite its high prevalence and high heritability (~70%), very little is known about the genetic basis of autoimmune hypothyroidism. To improve our understanding of the genetic signatures associated with HT development, we conducted a genome-wide association studies (GWAS) and follow-up analyses using ten...

Objective: Energy homeostasis is maintained through a complex interplay of processes, like energy substrate shuttling, breakdown, storage, and distribution. Thyroid hormones (THs) are key modulators of energy metabolism in the liver. In adult mouse liver, local hepatic TH availability is mediated via deiodinases, Dio1 and Dio3. During development, Dio3 is particularly important to provide protection from high concentration of maternal T3 and diminished in adulthood. However, l...