Endocrine Abstracts

Background: Graves’ disease is an autoimmune condition leading to hyperthyroidism and characteristically elevated TSH receptor antibody (TRAb). TRAb levels typically fall post-treatment with anti-thyroid drugs (ATDs) and are used in identifying risk of relapse. Tobacco smoking is a risk factor for reduced treatment efficacy of ATDs. We intended to evaluate the effect of smoking on changes in TRAb levels in patients treated for Graves’ disease.M...

Background: Serum thyroid-stimulating hormone (TSH) measurement is the diagnostic cornerstone for primary thyroid dysfunction. There is high inter-individual, but limited intra-individual variation in TSH concentrations, largely due to genetic factors. The currently used wide population-based reference intervals may lead to inappropriate management decisions.Methods: A polygenic score (PGS) including 59 genetic variants was used to calculate genetically-...

Background: Thyroid hormones interact with sympathetic stimulation for activating Brown Adipose Tissue (BAT) during cold exposure. Triiodothyronine (T3) upregulates the expression of Uncoupling Protein-1 (UCP1), a protein in BAT essential for heat production. Studies of human cold exposure have demonstrated both increased production and clearance of T3. Greenlandic hunters are characterized by mandatory chronic cold exposure, and cold adaptation is inevitable. Hence, they prov...

Introduction: There continues to be much discussion around optimization of thyroid hormone status in hypothyroid individuals. The ideal therapeutic goal in hypothyroidism would be to restore clinical and biochemical euthyroidism via physiologic thyroid hormone replacement. This concept may seem straightforward, but there are subtleties that have only recently been recognized. We here looked the way that FT4 and TSH related to each other in a large laboratory sample of people w...

Objectives: In CogThy, a longitudinal study on Graves’ disease, we previously showed that medial temporal lobe volumes (hippocampus and amygdala) are smaller in hyperthyroid patients than in matched thyroid-healthy participants. Longitudinally, we saw a volume increase in the patients in the sense of a recovery of the brain under treatment. In the present work, we conducted a corresponding analysis on the whole brain.Methods: Automatic segmentations...