SFEEU2024 Society for Endocrinology Clinical Update 2024 Workshop C: Disorders of the thyroid gland (11 abstracts)
Primary hodgkin lymphoma of the thyroid: a case report
Edgar Camilo Blanco Pimiento 1 , Maria Paula Ciliberti Artavia 1 , Luis Andres Dulcey Sarmiento 1 , Jaime Alberto Gomez Ayala 1 , Juan Sebastian Theran Leon 2 , Maria Camila Amaya Muñoz 1 , Angie Paola Lizcano Manrique 1 , Silvia Fernanda Castillo Goyeneche 1 , Maria Juliana Estevez Gomez 1 , Diego Andrey Acevedo Peña 1 , Anderson Felipe Arias Ariza 1 , Maria Camila Gomez 1 & Juan Alejandro Gomez 1
1Autonomous University of Bucaramanga., Bucaramanga, Colombia.; 2University of Santander, Bucaramanga, Colombia
Introduction: The thyroid lymphoma (TL) is a rare disease, accounting for less than 2% of thyroid neoplasms. The majority of cases are of the non-Hodgkin (NHL) B-cell lineage and large cell type.
Objective: To present a rare case documented in the literature of Primary Nodular Sclerosis Hodgkin Lymphoma (HL) of the thyroid, in a 20-year-old male patient.
Methods: The clinical history and records of the case, biopsy reports, immunohistochemistry, CT scans, and other extension studies were reviewed for subsequent analysis, summarization, and presentation.
Case Report: A 20-year-old male patient, born and residing in El Vigía/Mérida, presents with a clinical picture evolving over 6 months characterized by a sensation of pain and discomfort in the anterior neck region, profuse nocturnal sweating, and weight loss. Subsequently, there was a sudden increase in volume in the lateral cervical region, mainly on the right side, followed by progressive growth in the anterior neck region, reaching approximately 10 × 10 cm, accompanied by dysphagia. A cytology by fine needle aspiration was performed, yielding a presumptive diagnosis of chronic thyroiditis. Subsequently, a partial right lobectomy was carried out with a biopsy report indicating Hodgkin’s lymphoma (HL), nodular sclerosis type (October 2, 2014). Immunohistochemistry reported immunostaining for CD30 and CD15, suggesting primary thyroid HL. The patient underwent four cycles of ABVD protocol without complications. Upon completing the protocol, clinical, laboratory, and imaging reassessment were conducted, all of which were within normal limits. Remission has been maintained up to the present date.
Comment: Primary thyroid lymphoma is defined as a lymphoma that exclusively affects the thyroid gland (stage I) or invades tissues adjacent to the thyroid (stage II) (2). Our patient, as reported in the literature, was diagnosed in the context of a multinodular goiter. However, unlike the literature where the most common cases are Non-Hodgkin Lymphomas (3), this case involves Hodgkin Lymphoma, and it is in a young male patient, with no similar cases reported (4). The proposed treatment followed the standard protocol, intravenous polychemotherapy with doxorubicin, vinblastine, dacarbazine, and bleomycin (ABVD) for four cycles, followed by consolidation with radiotherapy, resulting in a satisfactory response.
Conclusion: We present a case of Primary Thyroid Lymphoma in a 20-year-old male patient, associated with a diagnosis of goiter. This is a rare and uncommon occurrence, both within the lymphoma group and among thyroid tumors.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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