Searchable abstracts of presentations at key conferences in endocrinology
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Society for Endocrinology Endocrine Update 2024

ea00100oc1 | Oral Communications | SFEEU2024

Making scents of hemi-anosmia in a woman presenting with secondary amenorrhoea

Tsoutsouki Jovanna , Comninos Alexander N , Phylactou Maria , Young Megan , Mills Edouard , Maria Newman Anastasia , Wynn Nyunt Sandhi , Koysombat Kanyada , Yeung Arthur , Patel Bijal , Howard Sasha , S Dhillo Waljit , Abbara Ali

Case history: A 25-year-old woman presented with secondary amenorrhoea present since aged 18yrs. She had spontaneous albeit late menarche aged 16yrs and five menstrual periods over the subsequent two-years, before complete menstrual cessation. She denied other medical history, psychological stress, excessive exercise, or regular medications. Notably, she reported normal sense of smell via her right nostril, but anosmia via her left nostril. Family history included a diagnosis ...

ea00100oc2 | Oral Communications | SFEEU2024

Non-islet cell tumour hypoglycaemia in adrenocortical carcinoma responding to combined growth hormone and corticosteroid therapy

Plowman C E , Soruna O , Pittaway J , Goodchild E , Shamash J , Chung TT , Abdel-Aziz T E , M Drake W

Case History: A 26-year-old woman with known metastatic adrenocortical carcinoma (ACC) was transferred to our department with recurrent severe hypoglycaemic episodes. Her ACC was diagnosed in 2018 and a 175 × 130 × 89 mm 1200 g mass was surgically resected (ENS@T stage-II, Weiss score-5, Ki-67 20%, Helsinki score-28). Her disease progressed despite adjuvant radiotherapy, mitotane and three chemotherapy regimens. In January 2023, she began experiencing episodes of pro...

ea00100oc3 | Oral Communications | SFEEU2024

Endocrine complexity in a case of MEN2A

Patel Aaran , Paleri Vinidh , Morganstein Daniel

Case History: A 53-year-old female with MEN2A (C634P mutation) and localised medullary thyroid cancer (MTC) was noted to have an adrenal nodule that was presumed by referring centre to be a phaeochromocytoma, given symptoms of anxiety and palpitations. There were also concerns about possible CushingÂ’s syndrome, as she reported fatigued, weight gain and a recent diagnosis of type 2 diabetes mellitus. Furthermore, she suffered a tibial plateau fracture which had been manage...

ea00100oc4 | Oral Communications | SFEEU2024

Peritoneal strumosis – balancing the management and preservation of fertility

Smith Daniel , Pittaway James , Berney Daniel , Krishnamurthy Mohan , Waterhouse Mona

Section 1: Case history : A 20-year-old Bangladeshi female presented to her GP with an 18-month history of nonspecific abdominal pain. She is nulligravida, not sexually active and reports no intermenstrual bleeding, dysmenorrhoea, menorrhagia or dysuria. Past medical history includes obesity, OSA and anosmia. Section 2: Investigations : The patient underwent a TVUS which demonstrated a large (158 × 84 × 156 mm) multiloculated lesion with a soli...

ea00100oc5 | Oral Communications | SFEEU2024

Young onset diabetes in non-obese individuals with fatty liver should be investigated for partial lipodystrophy

Chawla Mehul , Cho Billy , Patel Nishchil , Aziz Aftab , Oommen Suresh

Background: Monogenic familial Partial Lipodystrophy, a rare but clinically important cause of severe insulin resistance, is often underdiagnosed.Case: A 33 yearsÂ’ lady was referred to the diabetes clinic for sub-optimal glycaemic control. She was diagnosed with diabetes at 22 years of age, insidious in onset, and was managed as Type 2 diabetes for 10 years until presentation. She had a h/o oligomenorrhoea and was diagnosed with PCOS. She also had h...

ea00100oc6 | Oral Communications | SFEEU2024

Case of recurrence olfactory neuroblastoma presented with ACTH dependent Cushing syndrome

Ahmed Faroug , Murray Robert

A-49-year-old female with previous history of Olfactory neuroblastoma treated surgically in 2003 and no adjuvant treatment was given. She has a past medical history of depression, bilateral sensory neural hearing loss which is thought to be genetic. In Feb 2023 presented with uncontrol hypertension associated with hypokalaemia. Clinical examination showed BMI of 48.4, uncontrol high blood pressure despite using multiple antihypertensive medication. The initial assessment for t...

ea00100oc7 | Oral Communications | SFEEU2024

Managing endocrine neoplasia in mccune albright syndrome

Ahamed Sadiq Shafana , Carroll Paul

Case history: This 27 year female was first seen at GSTT in 2012, having had treatment for acromegaly due to a presumed GH-secreting adenoma in 2007 (Trans-sphenoidal surgery × 2, EBRT (2007), pegvisomant (2007-2012 (discontinued due to adverse effects)), & GammaKnife SRS (2011). GH and IGF-1 remained elevated and further treatment with pegvisomant/ SSA was declined. Abnormal bone growth with jaw and skull asymmetry was evident from age 10 years and final height was 1...

ea00100oc8 | Oral Communications | SFEEU2024

Dexamethasone-suppressed PET CT, using an 18F-ligand (‘CETO’), allows non-invasive diagnosis of unilateral aldosterone-producing adenoma, and prediction of complete clinical cure after adrenalectomy

Kearney Jessica , Goodchild Emily , Wu Xilin , Cheow Heok , Gurnell Mark , Drake William , Brown Morris J

Case History: A 57-year-old lady was referred with a 6-year history of hypertension and hypokalaemia necessitating hospital admission. Her medical background included breast cancer managed with chemotherapy, radiotherapy and surgery. She required Eplerenone 50 mg OD and Amlodipine 5 mg to control her hypertension, and Sando-K 2 tablets TDS to maintain normokalaemia. The patient was enrolled into the MATCH trial comparing adrenal vein sampling (AVS) with [11C]-metomi...

ea00100oc9 | Oral Communications | SFEEU2024

Mediastinal ectopic parathyroid in pregnancy

Kattakayam Freddy , Tildesley Rachel , Wynne Sian , Lim Rebecca , Woolley Steven , Shore Susannah

A 26-year-old primigravida woman presented with hypercalcaemia at 8-weeks gestation. Initial symptoms included nausea, vomiting and palpitations, with an admission serum adjusted calcium of 3.8 mmol/l. A biochemical diagnosis of primary hyperparathyroidism (PHPT) was supported by a raised PTH and a 24-hour urinary calcium-creatinine ratio of 2.0 mmol/ mmol, excluding familial hypocalciuric hypercalcaemia. Initial management with intravenous fluids and antiemetics was unable to...

ea00100oc10 | Oral Communications | SFEEU2024

Autoimmune hypothalamitis and hypophysitis due to SLE manifesting as arginine vasopressin deficiency and hypothalamic hyperphagia

Anandhakrishnan Ananthi , Akker Scott , Keddie Stephen , Monson John P , Gunganah Kirun

Clinical Case: A 30-year-old female was referred with subfertility and hypogonadotropic hypogonadism. She had systemic lupus erythematosus (SLE) and was on maintenance 5 mg prednisolone, having received intermittent high doses since her diagnosis in 2018. She reported 12 months of amenorrhea and reduced libido without galactorrhoea, despite regular menses since menarche aged13. This coincided with a rapid weight gain of 20 kg. On examination, her BMI was 36.8 kg/m2,...