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Endocrine Abstracts (2024) 99 RC6.3 | DOI: 10.1530/endoabs.99.RC6.3

1Erasmus University Medical Center, Rotterdam, Netherlands; 2ISGlobal, Barcelona, Spain; 3University Of Surrey, United Kingdom; 4Biodonostia Health Research Institute, San Sebastian, Spain; 5Jaume I University, Castelló de la Plana, Spain; 6Harvard T.H. Chan School of Public Health, Boston, United States


Background: Low maternal urinary iodine concentration (UIC) during pregnancy has been associated with lower child IQ and differences in brain morphology. However, UIC is highly variable as it is a reflection of 24-h urinary intake rather than long-term iodine status. Thyroglobulin (Tg) might be a more sensitive biomarker of the long-term maternal iodine status.

Aim: To study whether maternal Tg is associated with maternal and newborn thyroid hormone concentrations, offspring IQ and brain morphology and if these associations differ by UIC.

Methods: We selected participants from two population-based prospective cohorts: Generation R (the Netherlands) and INfancia y Medio Ambiente (INMA; Spain) with available measurements of maternal Tg and thyroid function at 13 weeks of gestation (n=4,438 women) or at birth (n=2,082 mother-child pairs), early childhood IQ (n=2,984; age 4.5 and 6 years) or late childhood IQ (n=2,569; age 9 and 13 years), and offspring brain morphology at 10 years (n=1,197). The associations of Tg with TSH and FT4 concentrations, IQ and brain MRI outcomes were studied with multivariable linear regression.

Results: Higher maternal Tg was associated with lower TSH (P<0.001), higher FT4 (P<0.001) and lower IQ in early childhood (-0.06 point per 1 ng/ml Tg, P=0.02). Tg was not associated with cord blood TSH or FT4, late childhood IQ or brain morphology. We found no clear evidence of effect modification by UIC.

Conclusions: Tg is associated with thyroid function during pregnancy and some markers of offspring neurodevelopment. However, further research should determine the added value of Tg in addition to UIC for defining iodine status.

Volume 99

26th European Congress of Endocrinology

Stockholm, Sweden
11 May 2024 - 14 May 2024

European Society of Endocrinology 

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