Endocrine Abstracts

Introduction: Coronavirus 2019 (COVID-19) is a potentially fatal infection caused by the acute respiratory syndrome virus coronavirus-2. Diabetes is one of the most distinct comorbidities of COVID-19. Our study describes the clinical characteristics of diabetic patients with COVID-19 to identify factors predictive of the occurrence of complications and death in these patients.

Materials and methods: This was a retrospective, monocentric study that included diabetic patients with Covid-19 referred to Mohamed VI International University Hospital from January 01 to December 21, 2021. We performed a multivariate analysis to quantify risk and identify significant predictive factors for complications and death.

Results: Our study included 60 patients. The sample was 63.33% male, with a median age of 67 years. At least one complication was present in 41.67% of patients, including death in 21.7% of subjects in the series. In univariate analysis, variables that were associated with the risk of complications occurring were: male gender, overweight or obesity, heart failure, otolaryngological signs, high percentageé of lung lesions on CT scan, low glomerular filtration rate and mean daily blood glucose >2.5g/l; while protective factors were insulin treatment and high saturation. Only male gender (OR: 28.55; P=0.005), overweight and obesityé (OR: 9.48; P=0.025), hyperleukocytosis (OR: 8.98; P=0.038) and blood glucose levels in the first 4 days persisted as a predictor of the occurrence of complications and death.

Conclusion: Male diabetic patients with high BMI admitted with hyperleukocytosis and persistent high blood glucose levels during hospitalization are more unlikely to progress to more severe COVID-19 and have a poor prognosis.