ECE2024 Poster Presentations Pituitary and Neuroendocrinology (120 abstracts)
Body weight in acromegaly – does it make any difference?
Sonia Kaniuka-Jakubowska 1 , claire higham 2,3 , Jessica Davis 4 , Tara Kearney 5 , Paul Loughrey 6,7 , Aisha Elamin 8 , Daniel Flanagan 9 , Mariusz Kaszubowski 10 , John Ayuk 11,12 , Steve M Orme 13 & John Wass 14
1Faculty of Medicine, Medical University of Gdansk, Department of Endocrinology and Internal Medicine, Gdansk, Poland; 2The Christie Hospital NHS Foundation Trust, Department of Endocrinology, Manchester, United Kingdom; 3The University of Manchester, Division of Cancer Sciences, Manchester, United Kingdom; 4Society for Endocrinology, Bristol, United Kingdom; 5Salford Royal Foundation Trust, Department of Endocrinology, Salford, United Kingdom; 6Queen’s University Belfast, Patrick G Johnston Centre for Cancer Research, Belfast, United Kingdom; 7Royal Victoria Hospital, Belfast Health and Social Care Trust, Regional Centre for Endocrinology and Diabetes, Belfast, United Kingdom; 8Sheffield Teaching Hospitals NHS Foundation Trust, Department of Endocrinology, Sheffield, United Kingdom; 9University Hospital Plymouth, Department of Endocrinology, Plymouth, United Kingdom; 10Faculty of Management and Economics, Gdansk University of Technology, Department of Economic Sciences, Gdansk, Poland; 11Birmingham Health Partners, Centre for Endocrinology, Diabetes and Metabolism, Birmingham, United Kingdom; 12Queen Elizabeth Hospital Birmingham, Department of Endocrinology, Birmingham, United Kingdom; 13St James’s University Hospital, Leeds Teaching Hospitals NHS Trust, Department of Endocrinology, Leeds Centre for Diabetes and Endocrinology, Leeds, United Kingdom; 14Oxford University Hospitals NHS Foundation Trust, Department of Endocrinology at the Oxford Centre for Diabetes, Endocrinology and Metabolism, Oxford, United Kingdom
Introduction: IGF-1 dependence on sex is a well-known fact; however, whether IGF-1 is also influenced by body weight is still questionable, and the mechanism of a potential relationship between GH, IGF-1 and body weight is not fully explained. The effect of gender (or rather oestrogens) on IGF-1 is visible in acromegaly - women are diagnosed at an older age than men (approximately 4 years) (potentially by suppressive effect on the axis of GH-IGF-1). The aim of the study was to assess whether BMI is a factor influencing the age of diagnosis of acromegaly - potentially by influencing (like oestrogens) the GH-IGF-1 relationship.
Materials and Methods: In a retrospective analysis of the UK Acromegaly Register (UKAR, 22 centres, 1997-2017) we enrolled 1136 patients (53.4% males) with available BMI results, which were reported +/- 2 years before diagnosis. We assessed the correlation between gender, BMI and age of diagnosis, age of first symptoms, diagnostic delay and the number of treatments in our selected group.
Results: We found, that that females are significantly older at diagnosis of acromegaly than males (approximately 4.3 years, p<0.001). However, there was no correlation between BMI and age of diagnosis (p=0.072). There was also no correlation between BMI and age of first symptoms (r=0.0947, P=0.002) and the time between first symptoms and diagnosis (r=0.0065; p=0.835). Patients with a higher BMI did not receive more treatment modalities in their course of follow-up (r=-0.0491; p=0.150).
Conclusions: BMI does not influence the age of diagnosis of acromegaly as the gender does. If oestrogens are responsible for a delay in diagnosis, it is probably by influencing the GH-IGF-1 axis - which is not visible in the BMI and age at diagnosis relationship. Mechanisms other than GH-IGF-1 should be considered when assessing differences in IGF-1 for different BMI. on behalf of the UKAR Steering Group 2024
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more