Endocrine Abstracts

Introduction: Literature data showed the association between serum cholecalciferol concentration and level of anxiety and depression in patients with classical types of diabetes mellitus. However, a clear relationship between these indicators in patients with latent autoimmune diabetes in adults (LADA) has not yet been established.

The aim of the study: To evaluate the dependence between level of anxiety, depression and cholecalciferol status in patients with LADA.

Material and methods: 42 patients with LADA (19 –LADA1, 23 –LADA2) and 25 practically healthy individuals were examined. In addition to general clinical research methods cholecalciferol status was evaluated. The levels of anxiety and depression were determined using the Spielberg’s and Beck’s questionnaires, respectively. The levels of anxiety were registered as level of situational anxiety and personal anxiety.

Results: Cholecalciferol level was registered 2.7 times lower in LADA1 group compared to control (14.63 [13.14; 15.98] ng/ml vs 40.00 [32.17; 53.00] ng/ml) and by 38.7% in LADA2 (24.51 [17.86; 32.93] ng/ml vs 40.00 [32.17; 53.00] ng/ml) (P<0.001). In LADA1 patients the level of cholecalciferol was lower by 40.3% (P< 0.01) compared to LADA2. The level of situational anxiety was 34.00 [27.75; 45.50] in LADA1 and 42.50 [23.00; 55.00] in LADA2 (higher by 25% than in patients with LADA1, P<0.05) and probably differed between LADA1/control and LADA2/control –control level 23.00 [16.00; 34.00] (decrease by 32.4% (P<0.01) and 45.9%, respectively (P<0.001)). The level of personal anxiety was higher in LADA1 group by 20.7% compared to control (29.00 [22.5; 40.25] vs 23.00 [20.00; 34.00]) (P<0.05) and did not significantly differ between LADA phenotypes. The level of depression was significantly higher in patients with LADA1 (17.00 [12.00; 22.50]) and LADA2 (12.00 [7.75; 15.00]) by 3.4 times and 2.4 times, respectively, compared with the control group (5.00 [3.00; 7.00]) (P<0.05); the difference between LADA phenotypes showed that depression level was higher by 41.7% in patients with LADA1 compared to LADA2 group (P<0.05). In patients with the LADA1 phenotype, negative correlations of medium strength were recorded between level of depression and C-peptide level (r=-0.348; р<0.05); level of depression and serum cholecalciferol indicator (r=-0.443; P<0.05). In LADA2, inverse correlations of medium strength were registered between high-density lipoprotein cholesterol indicator and level of depression (r=-0.328; р<0.05).

Conclusions: Level of anxiety and depression depends on serum cholecalciferol level (especially in LADA1 phenotype) which indicates the importance of its adequate supplementation in patients with LADA.