Endocrine Abstracts

Introduction: Endocrinopathies, characterized by dysfunctions in the endocrine system and its hormonal glands, emerge as a significant cause of secondary diabetes. These conditions induce complex disturbances in glucose metabolism, leading to insulin resistance or alterations in insulin production, pivotal factors in the development of secondary diabetes. This study aims to describe the etiological profiles of secondary diabetes and evaluate its evolution after treating the underlying endocrinopathies.

Patients and Methods: A retrospective study over a five-year period (2018-2023), involving 88 patients with secondary diabetes due to endocrinopathies, collected at the endocrinology department of Ibn Rochd University Hospital in Casablanca. Statistical analysis was conducted using the SPSS software.

Results: The mean age of the patients was 42.5 years±10.9, with a female predominance. The prevalence of diabetes was 47.7% in hypercortisolism, 36.3% in acromegaly, 11.3% in hyperthyroidism, and 4.5% in pheochromocytoma. The average duration of diabetes evolution was 5.6 years±3.5. Regarding glycemic control, 58% were unbalanced before treating the causal endocrinopathy, with an average HbA1C of 9.7%±2.4. After controlling the causal disease, glycemic control was achieved in 98.6% of patients with a transition to oral antidiabetic drugs. Degenerative assessment revealed diabetic retinopathy (12.8%), diabetic nephropathy (8.6%), and diabetic neuropathy (7.5%).

Conclusion: This study highlights the crucial importance of early recognition and treatment of endocrine disorders to prevent or effectively manage secondary diabetes. Targeted management of underlying endocrinopathies significantly improves glycemic control and reduces degenerative complications associated with secondary diabetes.