Endocrine Abstracts

Introduction: The effect of cholecalciferol on regulation of the lipid profile is one of the proposed mechanisms for the relationship between cholecalciferol deficiency and cardiovascular diseases in patients with diabetes mellitus.

The aim of the study: To evaluate the dependence between cholecalciferol status and dyslipidemia in patients with different phenotypes of latent autoimmune diabetes in adults (LADA).

Material and methods: 42 patients with LADA (19 –LADA1, 23 –LADA2) and 25 practically healthy individuals were examined. Lipidogram data (total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG) and cholecalciferol status were evaluated.

Results: Cholecalciferol level was registered 2.7 times lower in LADA1 group compared to control (14.63 [13.14; 15.98] ng/ml vs 40.00 [32.17; 53.00] ng/ml) and by 38.7% in LADA2 (24.51 [17.86; 32.93] ng/ml vs 40.00 [32.17; 53.00] ng/ml) (P<0.001). In LADA1 patients the level of cholecalciferol was lower by 40.3% (р < 0.01) compared to LADA2. The level of TC was 5.32 [4.83; 6.09] mmol/l in LADA1 and 5.23 [4.60; 6.10] mmol/l in LADA2 and probably differed between LADA1/control and LADA2/control (increase by 20.9% (P<0.001) and 18.9%, respectively (P<0.001)) without intergroup difference. The level of LDL-C was the highest in LADA2: by 74.2% compared with control and twice compared with LADA1 (P<0.001) and was 4.46 [3.99; 4.90] mmol/l; the level of HDL-C was 1.50 [1.15; 1.92] mmol/l and 1.05 [0.92; 1.13] mmol/l in LADA1 and LADA2, respectively, and was probably 19.8% lower in LADA1 (P<0.05) and by 43.9% in LADA2 (P<0.001) compared with control group, while in LADA1 the rate was 42.9% higher compared with LADA2 (P<0.01). The level of TG was significantly higher in patients with LADA1 and LADA2 by 84% and 48.1%, respectively, compared with the control group (P<0.05 and P<0.01, respectively) and did not differ significantly between LADA phenotypes, in the control group it was 0.81 [0.60; 1.10] mmol/l. In patients with the LADA1 phenotype, negative correlations of medium strength were recorded between TC and C-peptide level (r=-0.562; р < 0.05); LDL-C and cholecalciferol (r=-0.533; P<0.05); TG and IA-2 ab titers (r=-0.618; P<0.05). In LADA2, direct correlations of medium strength were registered between the HDL-C and cholecalciferol level (r=0.682; P<0.05); inverse correlations of medium strength –between LDL-C indicators and IA-2 ab titers (r=-0.500; р < 0.05).

Conclusions: Level of HDL-C is lower in patients with LADA2 phenotype as well as LDL-C is two times higher compare to LADA1 group. Lipid profile depends on cholecalciferol status, which indicates the importance of its adequate supplementation in patients with LADA.