ECE2024 Poster Presentations Diabetes, Obesity, Metabolism and Nutrition (130 abstracts)
The development of cardiovascular disease or cancer is correlated with higher FIB-4 in patients with T2DM
Katerina Stefanaki 1 , Dimitrios Karagiannakis 2 , Petrea Foteini 3 , Panagiota Zacharaki 1 , Alexandra Giannou 3 , Olympia Michalopoulou 1 , Paraskevi Kazakou 1 , Theodora Psaltopoulou 1 , Vasiliki Vasileiou 3 & Stavroula Paschou 1
1Alexandra Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece., Endocrine Unit and Diabetes Center, Department of Clinical Therapeutics, Athens, Greece; 2Laiko General Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece, Academic Department of Gastroenterology; 3Alexandra Hospital, Athens, Greece., Department of Endocrinology
Introduction: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a common feature of type 2 diabetes mellitus (T2DM). Liver fibrosis has been associated with an increased risk of cardiovascular diseases (CVD).
Aim: To investigate whether the fibrosis 4 index (FIB-4), a non-invasive marker of liver fibrosis, is associated with CVD or cancer in patients with T2DM.
Methods: Two hundred and nine consecutive T2DM patients were retrospectively evaluated. The mean time from the diagnosis to the first visit to our diabetes center was 9.83±8.6 years (median: 8.2 years; IQR: 12).
Results: One hundred and thirty-two (63.2%) patients were male and 77 (36.8%) were female. The mean age, body mass index (BMI), glycated hemoglobin (HbA1c), and FIB-4 were 64.3±11 years, 30.5±5.8 kg/m2, 7.8±2, and 1.15±0.5, respectively. One hundred and fifty (71.8%) patients had FIB-4 <1.3, and 59 (28.2%) had FIB-4 >1.3. Patients with CVD at the first visit were significantly older compared to patients without CVD (68.9±8.4 vs 62.9±11.4, respectively; P<0.001), while they had substantially higher FIB-4 (1.26±0.54 vs 1.08±0.51, respectively; P=0.007). Patients with cancer of any type at the first visit were older (68.2±9.5 vs 64.4±10.9 years, P=0.098), having significantly higher FIB-4 (1.37±0.6 vs 1.1±0.5, P=0.004) compared to those without cancer. A significant correlation was revealed between FIB-4> 1.3 and the presence of CVD (χ 2=4.92, P=0.027) or the presence of cancer (χ 2=7.603, P=0.006), respectively. In the multivariate analysis, the presence of CVD was found to be independently associated with sex (male: OR 0.261, 95% CI 0.095-0.717; P= 0.009), age (OR 1.057, 95% CI 1.008- 1.108; P= 0.021), and hypertension (OR 6.146, 95% CI 2.442-15.471; P<0.001).
Conclusion: T2DM patients who develop CVD or cancer are older with higher FIB-4. Older female patients with a history of hypertension are at a higher risk of developing CVD.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more