ECE2024 Poster Presentations Calcium and Bone (36 abstracts)
The association of vasomotor symptoms with fracture risk and bone mineral density in postmenopausal women: a systematic review and meta-analysis of observational studies
Panagiotis Anagnostis 1,1 , Konstantinos Lallas 2 , Anna Pappa 1 , Georgios Avgeris 1 , Kristina Beta 1 , Dimitrios Damakis 1 , Eirini Fountoukidou 1 , Maria Zidrou 1 , Irene Lambrinoudaki 3 & Dimitrios Goulis 1
1Aristotle University of Thessaloniki, 1st Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece; 2Aristotle University of Thessaloniki, Department of Medical Oncology, School of Medicine, Thessaloniki, Greece; 3National and Kapodistrian University of Athens, 2nd Department of Obstetrics and Gynecology, Athens, Greece
Purpose: Vasomotor symptoms (VMS) adversely affect postmenopausal quality of life. However, their impact on bone health has not been elucidated. This study aimed to systematically review and meta-analyze the evidence regarding the association of VMS with fracture risk and bone mineral density (BMD) in peri- and postmenopausal women.
Methods: A literature search was conducted in PubMed, Scopus and Cochrane databases until 31 August 2023. Fracture, low BMD (osteoporosis/osteopenia) and mean change in lumbar spine (LS) and femoral neck (FN) BMD were assessed. The results are presented as odds ratio (OR) and mean difference (MD), respectively, with a 95% confidence interval (95% CI). The I2 index quantified heterogeneity.
Results: Twenty studies were included in the qualitative and 12 in the quantitative analysis (n=49 659). No difference in fracture risk between women with and without VMS was found (n=5, OR 1.04, 95% CI 0.93–1.16, I2 16%). However, VMS were associated with low BMD (n=5, OR 1.54, 95% CI 1.42–1.67, I2 0%). Patients with VMS had lower LS BMD than those without VMS (MD −0.019 g/cm2, 95% CI −0.03 to −0.008, I2 85.2%). In contrast, there was no difference in FN BMD between groups (MD −0.010 g/cm2, 95% CI −0.021 to 0.001, I2 78.2%). These results were independent of VMS severity, age and study design. When the analysis was confined to studies that excluded menopausal hormone therapy use, the association with BMD remained significant.
Conclusions: The presence of VMS compromises bone health in postmenopausal women, since it is associated with low BMD.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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