ECE2024 Poster Presentations Adrenal and Cardiovascular Endocrinology (95 abstracts)
Description of recreational male and female athletes illicitly using androgenic anabolic steroids
LaustF Buhl 1 , Louise L Christensen 1 , Rikke Hjortebjerg 2 , Selma Hasific 3 , Clara Hjerrild 1 , Stefan Harders 4 , JonJ Rasmussen 5 , Dorte Glintborg 1 , Mariannes Andersen 1 , Caroline Kistorp 5 , Jess Lindholt 3 , Axel Diederichsen 6 & Jan Frystyk 1
1Odense University Hospital, Endocrinology, Odense; 2University of Southern Denmark, KMEB, Odense, Denmark; 3Odense University Hospital, Vascular Surgery, Odense; 4Aarhus University Hospital, Radiology, Aarhus, Denmark; 5Rigshospitalet, Endocrinology, København, Denmark; 6Odense University Hospital, Cardiology, Odense
Background: The illicit use of androgenic anabolic steroids (AAS) has increased significantly and is nowadays used by many recreational athletes. This raises concerns about the AAS-associated health risks, particularly cardiovascular complications. Therefore, we studied cardiovascular health in the broad population of Danish AAS-using recreational male and female athletes.
Methods: We conducted a cross-sectional study of 107 AAS users (27 women) and 58 healthy, age-matched controls (16 women) ≥18 years of age. Athletes were categorized as active AAS users or previous AAS users. Primary outcome was ultrasound-detected plaques of the carotid and femoral arteries. Secondary outcomes were computed tomography angiography (CCTA)-determined non-calcified and calcified plaques and cardiac function measured by echocardiography.
Results: The prevalence of ultrasound-determined plaques in the femoral artery in controls vs previous vs active AAS users were 0.0%, 6.3%, 16.0%, P=0.005, respectively, and in the carotid artery 1.8%, 18.8%, 12.0%, P=0.025, respectively. In subgroup analyses, long-term AAS use (>5 years) was significantly linked to non-calcified plaques (P=0.002) and coronary artery calcium scores (P=0.013). Additionally, both active and previous AAS users had higher prevalence of cardiac hypertrophy (controls vs previous vs active: 3.5%, 21.3%, 32.0%, P<0.001). Furthermore, a consistent pattern of decline in biventricular systolic function was observed across groups (controls vs previous vs active), with active AAS users displaying the lowest left ventricular ejection fraction (LVEF) (58.7%, 56.8%, 53.8%; P<0.001), LV global longitudinal strain (LV-GLS) (−19.8, −18.8, −17.6; P<0.001) and RV-GLS (−22.8, −20.9, −20.2; P<0.001). Women showed quantitatively similar changes as men, although not all findings achieved significance, probably due to a lower number of participants.
Conclusion: Long-term AAS use was linked to the development of peripheral and coronary atherosclerosis, cardiac hypertrophy, and reduced systolic and diastolic function. Parallel trends in results were evident in both men and women, underscoring that women share the same risk of developing cardiovascular disease as men.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more