ECE2024 Poster Presentations Reproductive and Developmental Endocrinology (45 abstracts)
1Clinic of Endocrinology, Diabetes and Metabolic Diseases, University Clinical Centre of Centre, National Centre for Infertility and Endocrinology of Gender, Belgrade, Serbia; 2Faculty of Medicine, University of Belgrade, Belgrade, Serbia; 3Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia; 4General Hospital of Novi Pazar, Department of Psychiatry, Novi Pazar, Serbia
Introduction: The interplay between obesity and hormones has a profound impact on womens reproductive health, reducing the likelihood of successful conception.
Methods: We performed a 6-month longitudinal study. The inclusion criteria were: women aged 20-40 with infertility, regular anovulatory menstrual cycles, BMI 35-40 kg/m², unrelated to other diseases. 30 eligible women were categorized into three groups: Group 1 (G1) received motivational interviews, hospitalizations, and nutritionist check-ups; Group 2 (G2) underwent hospitalization and nutritionist check-ups, while Group 3 (G3) served as the control without any interventions.
Results: G1-mean age 32.2±5.5, mean starting BMI (BMI1) 35.6±6.4 kg/m², G2-mean age 36.4±4.1, mean BMI1 38.2±4.9 kg/m², G3-mean age 33.7±4.9, mean BMI1 35±1.0 kg/m², with no difference in age or BMI between the groups (P>0.05). After 6 months, G1 lost 15.5±7.4% of their initial body weight (BW) i.e 14.5±9.09% of the BMI1, G2 lost 10.9±8.07% BW i.e. 11.05±8.2% BMI1, G3 lost 0.38±1.8% BW i.e. 0.41±1.08% BMI1 (P<0.0001). When compared based on percentage of BMI loss, there was a difference between G1-G3 (P<0.001), G1-G2 (P<0.01), but no difference between G2-G3 (P>0.05). When compared based on percentage of BW loss, there was a difference between G1-G3 (P<0.0001), G2-G3 (P=0.02), but no difference between G1-G2 was observed (P>0.05). After 6 months, only in G1 progesterone reached ovulatory levels 10.88± 8.72 nmol/l (P<0.05), where in G2/8.6±5.9 nmol/l and G3/3.4±1.65 nmol/l, this effect was absent (P<0.05). Progesterone levels were significantly higher in G1 than in G3 (P=0.034) although there was no difference between the groups G1 and G2 (P>0.05) and G2 and G3 (P>0.05). The number of hospitalizations with motivational interview was a linear predictor of percentage of weight loss (P<0.0001, B=3.785, 95% CI 2.08-5.48, OR 4.553).
Conclussion: The motivational interview emerges as a promising and effective method with a significant role in the reduction of excessive body weight. The combined approach of motivational interviews and hospitalization presents a synergistic strategy in the comprehensive treatment of obesity and its associated reproductive health challenges.