ECE2024 Poster Presentations Environmental Endocrinology (6 abstracts)
The influence of environmental and behavioral factors on male infertility associated hormones
Dinu Draganescu Daniela 1 , Adrian Albulescu 2 , Suzana Vladoiu 1 , Fudulu Alina 2 , Anca Botezatu 2 , Ples Adriana 2 , Iancu Iulia Virginia 2 , Cristina Stancu 1 , Andrei Muresan 1 , Oana-Monica Popa 1 , Luminita Udrea 1 , Ioana Adina Rugescu 2 , Dinu Draganescu Daria 1 , Ruxandra Dumitrescu 2 & Corin Badiu 1,3
1National Institute of Endocrinology; 2Stefan S Nicolau Institute of Virology; 3Carol Davila University of Medicine and Pharmacy, Endocrinology, Bucuresti
Male infertility arises as a global public health in the context of the dramatic decrease in birth rates. However, the underlying causes of male infertility remain unknown in many cases. An increasing number of studies suggest that environmental and behavioral factors (smoking, drinking, etc) may affect the hormone levels and other pathways involved in male fertility. The aim of this study was to investigate the influence of various environmental factors and hormonal profiles in a cohort of idiopathic infertile men. This study included 33 blood and seminal samples from patients with idiopathic infertility and 21 from the control group. Infertile group (age between 20-55 years old) inclusion criteria were: modified seminal parameters, failure to achieve pregnancy after at least one year of trying, while the exclusion criteria was: known causes for infertility. The patients filled out a standardized questionnaire designed to gather information regarding their age, smoking and drinking habits, radio frequency (RF) exposure/day, medical history, and place of residence. The percentage of smoking patients was 18.18% in infertile group, respectively 28.57% in control group, while regarding alcohol behavior, 18.18% of infertile patients reported consuming alcohol, and 19,04% in control group. The hormonal profile varies depending on a couple of behavioral/environmental factors. Estradiol levels were slightly decreased in the control group with less than 4 hours of RF exposure/day, while the infertile group displayed an opposite image, with higher levels in the case of more than 4 hours/day RF exposure. Estradiol also displayed a significant increase in the patients who consume alcoholic beverages, regardless of their fertility status (P=0.0292). Free testosterone also varies between drinkers and non-drinkers, regardless of their fertility status as well (P=0.0233). Testosterone levels also displayed variation between infertile RF exposure groups, with increased levels in the >4 hours/day group (P=0.0276). The same trend was observed in the case of free testosterone (P=0.0029). Other factors that impacts testosterone levels are smoking behavior, with a significant increase in the case of smokers (P=0.0233), and drinking behavior, with an increase in the case of alcohol consumption (P=0.0398) The landscape of male infertility should take into account environmental and behavioral factors. This preliminary study showed an important role of these factors in modifying hormone expression levels, especially testosterone, which ultimately may affect the quality of the reproductive function.
Volume 99
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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