Endocrine Abstracts

Introduction: Infections are very frequent in Cushing’s disease with impact on quality of life.

Objective: The aim of our study is to describe infectious manifestations in Cushing’s disease

Material and methods: Retrospective study of 51 patients diagnosed for Cushing’s disease followed at the Ibn Rochd CHU Endocrinology from Casablanca from 2012 to 2023. Infectious complications were detected either at diagnosis or during monitoring. The statistical analysis was done by the SPSS version 25 software.

Results: We included 51 patients including 45 women and 6 men, the average age of patients was 36.20 years (17-69). The average seniority of the disease was 2.5 years. The average Clu was 657 mg/24 hours (116.8 - 2196). To pituitary MRI: macroadenoma in 27 patients, microadenoma in 21 patients and normal in 5 patients. The infectious complications found are: mycoses of large folds 66.67%(n= 34), intertrigo interdes macerated 72.55%(n= 37), cystitis 39.21%(n= 20), acute pyelonephritis 17.65%(n= 9), infection Pulmonary 27.45% (n= 14), dental abscesses 11.76% (n= 6), erysipelas of the leg 25.49% (n= 13), candidosal vulvovaginitis 64.70% (n= 33), esophageal candidiasis in 3 patients, 2 patients are complicated by post -operative meningitis of surgery by transphenoidal route. All our patients have healing with antibiotic and/or antifungal treatment and the management of Cushing’s disease.

Conclusion: Infectious complications are frequent in Cushing’s disease, hence the interest of early screening and adequate management in order to improve the quality of life in its patients.