Evaluation of the clinical and biological profile in patients with congenital pituitary deficiency

Yosra Hasni; Hamza Elfekih; Oumayma Zarrouk; Yasmine Salem; Abdallah Jihene Ben; Saoussen Mrad; Amira Yanes; Hadj Slama Nassim Ben; Salima Ferchichi; Chaieb Molka Chadli

doi:10.1530/endoabs.99.EP96

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Endocrine Abstracts (2024) 99 EP96 | DOI: 10.1530/endoabs.99.EP96

ECE2024 Eposter Presentations Pituitary and Neuroendocrinology (214 abstracts)

Evaluation of the clinical and biological profile in patients with congenital pituitary deficiency

Yosra Hasni ¹ , Hamza Elfekih ¹ , Oumayma Zarrouk ¹ , Yasmine Salem ² , Jihene Ben Abdallah ² , Saoussen Mrad ² , Amira Yanes ¹ , Nassim Ben Hadj Slama ¹ , Salima Ferchichi ² & Molka Chadli Chaieb ¹

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¹University Hospital of Farhat Hached, Endocrinology Departement, Sousse; ²University Hospital of Farhat Hached, Biochemistry Laboratory, Sousse

Introduction: Pituitary deficiency, or hypopituitarism, is defined by insufficient synthesis or secretion of one or more anterior pituitary hormones. These hormones, including growth hormone, are considerably involved, directly and indirectly, in several metabolisms such as hepatic, carbohydrate, lipid metabolisms and the regulation of protein synthesis. The objective of this study was to study the clinical and biological profiles of patients followed for anterior pituitary insufficiency.

Methods: A cross-sectional study was conducted, including patients followed in the Endocrinology department of Farhat Hached University Hospital, Sousse for isolated GH deficiency and/or associated with other anterior pituitary hormonal deficiencies. Data were collected over a period of 9 months from January to September 2022.

Results: Our study included 55 subjects divided into 3 groups: 15 patients followed for an isolated GH deficiency (G1), 20 followed for multiple congenital pituitary deficiencies (G2) and 20 control subjects (control group). The average age of our patients at the time of diagnosis was eleven and a half. A male predominance was noted in G1 (73.3%) and G2 (60%). The evaluation of clinical characteristics such as age, body mass index, blood pressure and waist circumference did not show a statistically significant difference between G1 and G2. The evaluation of metabolic, renal, hepatic, calcium and lipid balance did not show any significant difference between the three groups of the study apart from alkaline phosphatase which was higher in G1 (200.4±106.1 U/l) compared to G2 (169.6±94.1 U/l) and the control group (72.7±23.1 U/l) with a statistically significant difference between the control group and each of the other two groups. Comparing hormonal parameters between G2 and control group, we found a significant difference linked to the male sex in thyrotropic insufficiency, as well as a lower level of sex hormones in both sexes. No significant difference was found between these two groups for gonadotropins, prolactin, and cortisol.

Conclusions: The clinical and biological profile of patients with congenital pituitary deficiency was almost similar between the group with isolated GH deficiency and the group with combined anterior pituitary deficiencies. For hormonal parameters, only TSH, FT4 and sex hormones were different between the two groups.