ECE2024 Eposter Presentations Diabetes, Obesity, Metabolism and Nutrition (383 abstracts)
The controlled attenuation parameter (CAP) and metabolic syndrome: is there a link?
Meriam Dalhoum 1 , Olfa Berriche 1 , Rim Ben Othmen 1 , Emna Talbi 2 , Raja Tlili 3 , Sahar Hamza 3 , Amel Gammoudi 1 , Awatef Kacem 2 , Lamia Kallel 3 & Henda Jamoussi 1
1National Institute of Nutrition in Tunis, Human Obesity Research Unit, Tunis, Tunisia; 2National Institute of Nutrition in Tunis, Biochemistry Laboratory, Tunis, Tunisia; 3Mahmoud El Matri Hospital, Ariana, Tunis, Gastroenterology Department, Tunis, Tunisia
Introduction: The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing worldwide. Since its earliest descriptions, NAFLD has been associated with the metabolic syndrome and its components.
Objective: To assess the relationship between Controlled Attenuation Parameter (CAP) values and the various components of metabolic syndrome.
Materials and methods: We carried out a longitudinal study including 161 patients with non-alcoholic fatty liver detected by a fibroscan using the CAP function (threshold >248 dB/m for M and XL probes) and followed up for obesity at the Human Obesity Research Unit of the National Institute of Nutrition in Tunis. They were interviewed, anthropometrically measured (weight, height, body mass index (BMI), waist circumference (WC)) and biologically assessed.
Results: The mean age of our population was 49.23±11.15 years. Patients were divided into 143 women (88.8%) and 18 men (11.2%). Mean BMI was 41.14±6.37 kg/m2; and mean WC was 119.21±14.82 cm. Among our patients, 59 (36.6%) had diabetes, 66 (41%) were hypertensive, 63 (39.1%) had hypertriglyceridemia and 90 (55.9%) had hypo-HDL cholesterol. The prevalence of metabolic syndrome in our patients was 57.9% and the severity of hepatic steatosis increased significantly with the prevalence of metabolic syndrome (P<0.001). In univariate analysis, there was a statistically significant positive linear relationship between CAP and the majority of metabolic syndrome parameters except hypoHDL cholesterol, CAP values were significantly higher in patients with diabetes, hypertension and hypertriglyceridemia respectively (respectively P=0.004; P=0.02 and P=0.016 respectively).
Conclusion: Our study shows that there is a significant correlation between CAP values and the various parameters of the metabolic syndrome, which thus favors the onset of hepatic steatosis in obese patients, justifying comprehensive management targeting all risk factors.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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