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Endocrine Abstracts (2024) 99 EP908 | DOI: 10.1530/endoabs.99.EP908

1CHU Ibn Rochd, Casablanca, Morocco; 2CHU Ibn Rochd, Department of Endocrinology and Metabolic Diseases, Casablanca, Morocco


Introduction: Acromegaly is a rare disease with an insidious course characterized by several complications that determine its prognosis. This is a case study to evaluate the cardiovacular impact on 76 patients treated at CHU Ibn Rochd Casablanca.

Material and methods: This is a retrospective study of 76 cases of acromegaly followed in the endocrinology department of Ibn Rochd University Hospital from January 2005 to October 2023. All our patients had an ECG; Heart echo and metabolic assessment. The statistical analysis was carried out using EXCEL software.

Results: The average age was 49 years with a sex ratio F/M of: 0.33. The average BMI rate was 29 kg/m² with overweight in 12 patients (20.8%), and obesity in 23 patients (41.6%). The average duration of the disease was 9 and a half years; The average IGF1 level was 2.3 times normal and the etiological diagnosis was a pituitary adenoma in all patients. Hypertension was found in 33%, rhythm and/or conduction disorders were observed in 52 % of patients, hypertensive cardiomyopathy in 16%. Metabolic assessment: pre-diabetes in 10 patients (17.8%) and diabetes in 28 patients (50%). Dyslipidemia was observed in 20 patients (35.7%).

Discussion: Among the cardiovascular complications, hypertension is frequently found; it is more frequent as the disease is older, the GH is higher and the age of the patients is greater. 26 % patients had at least 2 risk factors and 9 % were affected by 4 risk factors These complications are the consequences of the effects of permanent hypersecretion of growth hormone and growth factor (IGF-1) as well as late treatment

Conclusions: Cardiovascular complications of acromegaly are common and must be screened systematically in order to prevent the morbidity and mortality of this disease.

Volume 99

26th European Congress of Endocrinology

Stockholm, Sweden
11 May 2024 - 14 May 2024

European Society of Endocrinology 

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