Endocrine Abstracts

Introduction: Acromegaly is a rare disease with an insidious course characterized by several complications that determine its prognosis. This is a case study to evaluate the cardiovacular impact on 76 patients treated at CHU Ibn Rochd Casablanca.

Material and methods: This is a retrospective study of 76 cases of acromegaly followed in the endocrinology department of Ibn Rochd University Hospital from January 2005 to October 2023. All our patients had an ECG; Heart echo and metabolic assessment. The statistical analysis was carried out using EXCEL software.

Results: The average age was 49 years with a sex ratio F/M of: 0.33. The average BMI rate was 29 kg/m² with overweight in 12 patients (20.8%), and obesity in 23 patients (41.6%). The average duration of the disease was 9 and a half years; The average IGF1 level was 2.3 times normal and the etiological diagnosis was a pituitary adenoma in all patients. Hypertension was found in 33%, rhythm and/or conduction disorders were observed in 52 % of patients, hypertensive cardiomyopathy in 16%. Metabolic assessment: pre-diabetes in 10 patients (17.8%) and diabetes in 28 patients (50%). Dyslipidemia was observed in 20 patients (35.7%).

Discussion: Among the cardiovascular complications, hypertension is frequently found; it is more frequent as the disease is older, the GH is higher and the age of the patients is greater. 26 % patients had at least 2 risk factors and 9 % were affected by 4 risk factors These complications are the consequences of the effects of permanent hypersecretion of growth hormone and growth factor (IGF-1) as well as late treatment

Conclusions: Cardiovascular complications of acromegaly are common and must be screened systematically in order to prevent the morbidity and mortality of this disease.