Assessment of vitamin d status and depression grade in patients with diabetes mellitus type 2 in chronic stress conditions

Maryna Bobryk; Viktoriia Yerokhovych; Dmytro Malyi; Iuliia Komisarenko

doi:10.1530/endoabs.99.EP852

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Endocrine Abstracts (2024) 99 EP852 | DOI: 10.1530/endoabs.99.EP852

ECE2024 Eposter Presentations Diabetes, Obesity, Metabolism and Nutrition (383 abstracts)

Assessment of vitamin d status and depression grade in patients with diabetes mellitus type 2 in chronic stress conditions

Maryna Bobryk ¹ , Viktoriia Yerokhovych ¹ , Dmytro Malyi ² & Iuliia Komisarenko ¹

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¹Bogomoletz National Medical University, Endocrinology, Kyiv, Ukraine; ²Bogomoletz National Medical University, Dentistry, Institute of Postgraduate Education, Kyiv, Ukraine

Introduction: Ukrainian population is facing many challenges of war including chronic stress, D deficit, often unavailability of medical care. In these conditions some diagnostic disadvantages of Diabetes Mellitus type 2 (DM 2) patients’ status are also observed¹. According to Ukrainian Consensus on Diagnosis and Management of Vitamin D Deficiency in Adults, approximately 20% of Ukrainian population has Vit D deficit (VDD) and 27% Vit D insufficiency (VDI)².

Aim of the study: To evaluate 25-hydroxyvitamin D level in DM 2 patients with different severity of depression.

Methods: 121 DM 2 patients aged 19-75 years were examined. We studied the level of 25 hydroxycholecalciferol (25-OH D) using Chemiluminescent immunoassay. Diagnosis of VDD and VDI were made according to Clinical Practice in the Prevention, Diagnosis and Treatment of Vitamin D Deficiency: A Central and Eastern European Expert Consensus Statement³. Grade of depression was evaluated with Depression, Anxiety and Stress Scale, DASS 21. There were 5 grades of depression: Normal, Mild, Moderate, Severe, Extreme.

Results: Distribution of patients according to the severity of depression: 6 patients had no symptoms of depression, 24 patients had Mild, 43 Moderate, 42 Severe and 6 Extreme grade of depression. We observed inverse relationship between 25-ОН D level and Depression grade in DM 2 patients, from 28.05±2.6 ng/ml (correspond to VDI) in Mild depression to 9.5±0.4 ng/ml (correspond to VDD) in Extreme depression (P< 0,001); inverse relationship between 25-ОН D level and Body Mass index (BMI) (rSpearman= -0.304, P=0.001).

Conclusion: In chronic stress patients with DM 2 need treatment with vitamin D and consultation of psychologist.

Keywords: 25-OH D, Vit D deficit, Vit D insufficiency, Depression, Diabetes Mellitus, DASS21

References: 1. Kohut AO, Chaban OS, Dolynskyi RG, Sandal OS, Bursa AI, Bobryk MI, Vertel AV. The Features of Posttraumatic Stress Disorder Development in Patients With Diabetes Mellitus 2 Type. Wiad Lek. 2022;75(8 pt 1):1903-1907. https://doi.org/10.36740/wlek202208115 2. Grygorieva, N.; Tronko, M.; Kovalenko, V.; Komisarenko, S.; Tatarchuk, T.; Dedukh, N.; Veliky, M.; Strafun, S.; Komisarenko, Y.; Kalashnikov, A.; et al. Ukrainian Consensus on Diagnosis and Management of Vitamin D Deficiency in Adults. Nutrients 2024, 16, 270. https://doi.org/10.3390/nu16020270 3. Pludowski P, Takacs I, Boyanov M, Belaya Z, Diaconu CC, Mokhort T, Zherdova N, Rasa I, Payer J, Pilz S. Clinical Practice in the Prevention, Diagnosis and Treatment of Vitamin D Deficiency: A Central and Eastern European Expert Consensus Statement. Nutrients. 2022 Apr 2;14(7):1483. doi: https://doi.org/10.3 390/nu14071483.