ECE2024 Eposter Presentations Diabetes, Obesity, Metabolism and Nutrition (383 abstracts)
Interrelation of TNF-α concentrations with the onset and progression of diabetic complications
Elvira Ibragimova 1 , Talat Saatov 1 , Timur Alimov 1,2 , Sanobar Irgasheva 1,3 , Tokhir Ishankhodjaev 1 , Gulnora Artykbaeva 1 , Nigora Maksutova 4 , Abdunabi Tashtemirov 1 & Zulaykho Shamansurova 1,5
1Institute of Biophysics and Biochemistry, Mirzo Ulugbek National University of Uzbekistan, Tashkent, Uzbekistan; 2Republican Specialized Scientific Practical Medical Center of Hematology and Blood Transfusion, Uzbekistan Public Healthcare Ministry, Tashkent, Uzbekistan; 3Alfraganus University, Tashkent, Uzbekistan; 4Ya. Kh. Turakulov Center for Scientific and Clinical Study of Endocrinology, Uzbekistan Public Healthcare Ministry, Tashkent, Uzbekistan; 5Central Asian University, Tashkent, Uzbekistan
As a cytokine, TNF-α plays a role of key anti-inflammatory mediator involved in the onset and progression of insulin resistance and type 2 diabetes mellitus. TNF-α is known to inhibit insulin-stimulated of auto-phosphorylation of insulin receptors by tyrosine kinase; as the result, insulin sensitivity decreases in its turn resulting in insulin resistance and glucose transport damage. TNF-α is a trigger in the onset of obesity, diabetes mellitus and its complications. Studies on concentrations of TNF-α in peripheral blood are of high importance in assessment of extent in type 2 diabetes mellitus progression.
Materials and methods: 68 patients with type 2 diabetes mellitus, 50 persons with diabetic neuropathy of various degrees and 18 persons without any 2DM complications among them, were examined. Non-diabetics were included into the control group. ELISA was used to determine TNF-α concentrations in the blood serum of the examinees.
Results: Determination of TNF-α concentrations in blood serum of the examinees demonstrated their significant increase as compared to those in the non-diabetics (3.05±0.44 vs 1.1±0.05 pg/ml). In patients with moderate diabetic neuropathy, the serum concentrations of TNF-α turned out significantly lower than those in patients with severe disease (3.62±0.89 vs 7.13±1.14 pg/ml). Thus, paralleling disorders in carbohydrate and lipid metabolism in 2DM, concentrations of TNF-α in blood serum of the patients were found to be in direct dependence with the disease severity.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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