ECE2024 Eposter Presentations Calcium and Bone (102 abstracts)
Risk of osteoporotic fractures among patients with thyroid cancer: a nationwide population-based study
Eun Kyung Lee 1 , Eu Jeong Ku 2 , Won Sang Yoo 3 , Yu Been Hwang 4 , Subin Jang 4 , Jooyoung Lee 4 , Shinje Moon 5 , Hwa Young Ahn 6 & Young Joo Park 7
1National Cancer Center, Center for Thyroid Cancer, Department of Internal Medicine, Goyang; 2Seoul National University Hospital Healthcare System Gangnam Center; 3Dankook University College of Medicine; 4Chung-Ang University College of Statistics; 5Hallym University College of Medicine; 6Chung-Ang University College of Medicine; 7Seoul National University College of Medicine
Background: The association between thyroid cancer and skeletal outcomes has not been thoroughly investigated. We aimed to investigate the risk of osteoporotic fractures in patients with thyroid cancer compared with a matched control group.
Methods: This retrospective cohort study included 2,514 patients with thyroid cancer and 75,420 matched controls from the Korean National Health Insurance Service-National Sample Cohort (NHIS-NSC, 2006-2019). Rates of osteoporotic fractures were analysed and associations with levothyroxine dose were evaluated.
Results: Patients with thyroid cancer had a significantly lower risk of fracture compared with the control group (hazard ratio [HR] 0.81, 95% confidence interval [CI]: 0.69 to 0.94, P=0.006). The group diagnosed with thyroid cancer after the age of 50 (older cancer group) had a significantly lower risk of fractures compared with the control group (HR: 0.72, 95% CI: 0.6 to 0.85, P<0.001), especially for spine fractures (HR: 0.66, 95% CI: 0.51 to 0.85, P=0.001). The older cancer group started osteoporosis treatment earlier than the control group (65.5 ± 7.5 vs 67.3 ± 7.6 years, P<0.001). In addition, a lower dose of levothyroxine was associated with a lower risk of fracture.
Conclusions: In the actual clinical setting, the risk of fracture in women diagnosed with thyroid cancer after the age of 50 years was lower than in the control group, which is interpreted as a phenomenon caused by more proactive osteoporosis treatment in postmenopausal women with thyroid cancer.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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