Endocrine Abstracts

Introduction: Micropenis represents a diagnostic and therapeutic challenge. The Diagnosis is based on the measurement of penile length. Defined by normal structure, abnormal size: -2 standard deviation (SD) below of average of age. The aim of our study is to evaluate the etiological profile and therapeutic efficacy.

Patients and methods: It’s a retrospective and descriptive study including 55 childrens and adolescents with micropenis, treated with hormonal therapy followed up in the Department of Endocrinology-Diabetology and Nutrition of Mohammed VI University, Hospital Center, Oujda, in Morrocco, between 2014 and 2023. All patients in our series were received a clinical examination including measurement of penis size, biological evaluation and bone age. The statistical analysis was done by SPSS version 21.

Results: The average age of our study group was 13±7 years. Forty-eights percent of the patients were the adolescents. The most frequent reasons for consultation were the Growth retardation (55%) then testicular abnormality (22%). The mean penile size is -2.40±0.41 SD. Nine percent of the patients have penis anomaly and 25% have testicule anomaly. The luteinizing hormone-releasing hormone (LHRH) test was performed in 38% of the patients. The exploration revealed that idiopathic micropenis is the most frequent etiology (29%), followed by growth hormone deficiency (21%). All patients of our group were put on hormonal treatment. The transdermal dihydrotestosterone was administred at 60% of the patients and 40% at the intramuscular injection of testoterone enanthate. The post treatement evaluation revealed that the mean penile size is -1.39±0.75 SD. Therapeutic efficacy was observed in 70% of patients (P<0.05).

Discussion and conclusion: The Early diagnosis of micropenis is based on a thorough clinical examination of all newborns and infants, for early and appropriate management. The most etiology of Micropenis is idiopathic but it is a diagnosis of elimination. The hormonal treatment is not always effective in the puberty, hence the importance of psychological support.

Key words: Micropenis -Growth Hormone- Testosterone Enanthate.

References: 1. Nihal, H., & Selim, K. (2013). Micropenis: Etiology, Diagnosis and Treatment Approaches. Journal of Clinical Research in Pediatric Endocrinology, 5(4), 217–223. doi:10.4274/jcrpe.11352. Stancampiano MR, Suzuki K, O’Toole S, Russo G, Yamada G, Faisal Ahmed S. Congenital Micropenis: Etiology And Management. J Endocr Soc. 2021 Nov 15;6(2):bvab172.