Endocrine Abstracts

Introduction: COVID-19 is the disease caused by a new coronavirus, now called severe acute respiratory syndrome coronavirus. Long COVID is a wide range of new, returning, or ongoing health problems that people experience after being infected with the virus that causes COVID-19. Diabetic nephropathy(DN) is a frequent comorbidity in patients with COVID-19.

Aim: The aim of the present work was to study the relationship between chronic kidney disease (CKD) and SARS-CoV-2 infection and early detection of CKD.

Methods: A cohort of patients were studied with confirmed COVID-19 infection examined at the Department of infectious disease, Zangiata Infectious Diseases Hospital, Tashkent region. Bloodwithdrawalwas carried outwhen the recruited adolescents tested negative for the SARS-CoV-2 (‘post-infected COVID-19’), 90 to 95 days after the last molecular test.

Results: 120 adult patients were examined: 80 patients with type 2 diabetes complicated by CKD (main group) who had suffered COVID-19, and 30 patients with type 2 diabetes complicated by CKD who had not suffered COVID-19 (control group). Patients in the main (COVID-19 in combination with T2DM) and control groups (T2DM) did not differ, as expected, in gender (7 men (33.3%) in each group; P=1.00), age (64.3± 8.50 and 62.3±5.96 years; P=0.333), HbA1c level (9.8±2.09 and 9.6±1.82%; P=0.670), as well as body mass index (30.7±5.15 and 29.2±5.83 kg/m²; P=0.131). Both groups had the same number of patients with diabetes experience of more than 5 years (16 people each, or 76.2%; P=1.00). The study and control groups did not differ in the frequency of detection of such diabetes complications as nephropathy (10 (47.6%) and 11 (52.4%); P=0.762), retinopathy (7 (33.3%) and 11 (52.4%); P=0.213) and polyneuropathy (16 (76.2%) and 11 (52.4%); P=0.110). Analysis of tissue growth factor (TGF-β1) indicators in patients with covid 19 and diabetic nephropathy showed that TGF-β1 in this group was 1.9 times higher than normal (54.7±6.1 ng/ml), compared with the control group it was 0.65 times higher (P< 0.05). Scientific studies have determined the levels of sensitivity and specificity of TGF-β1 as diagnostic markers in the early detection of CKD.

Conclusions: The results of our study are in accordance with those of the literature regarding in early diagnosis and prevention is the use in clinical practice of highly diagnostic laboratory research methods to identify CKD of various etiologies among the population.