Endocrine Abstracts

Objective: Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) it’s a histological entity that describes a low-aggressive neoplasm previously classified as encapsulated follicular variant of papillary thyroid carcinoma and well differentiated tumour of uncertain malignant potential. The preoperative diagnosis it’s difficult, and if we suspect it hemithyroidectomy or lobectomy it’s the therapeutic management of choice. Therefore, we will evaluate the features and diagnostic-therapeutic management of patients with NIFTP.

Materials and Methods: Retrospective observational study with 23 patients with NIFTP diagnosis in Granada’s hospitals between the years 2016 and 2022. Demographic (sex, age), radiological (pre and postoperative ultrasonography), anatomopathological (pre and postoperative sample type, tumoral size) and therapeutic (indication and operation type, postoperative thyroglobulin and treatment and follow-up) variables were collected.

Results: 23 patients with NIFTP (73.9% females, 50±13 years). In the preoperative ultrasonography the nodules were classified in TI-RADs 4 and 5 in 47.8% and 8.7% respectively. Fine-needle aspiration (FNA) results were 4.3% for Bethesda I, 34.8% for Bethesda II, 21.7% Bethesda III, 17.4% Bethesda IV, 17.4% Bethesda V and 4.3% Bethesda VI. The surgical indication was PAAF’s result in 60.9% of the patients, being total thyroidectomy the technique of choice in 65.2% of patients. The average size of the tumours was 31.8±14.7 mm. After surgery, 65.2% had performed ultrasonography and thyroglobulin levels, and three cases were treated with radioiodine. 87% were followed-up after treatment.

Conclusions: Our study confirms the difficulty in suspecting NIFPT presurgically, that’s why total thyroidectomy was performed in more than a half of patients, and follow-up is subsequently performed in the majority of cases.