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Endocrine Abstracts (2024) 99 EP485 | DOI: 10.1530/endoabs.99.EP485

1ENT department Farhat Hached hospital, Sousse, Tunisia; 2Endocrinology department Farhat Hached hospital, Sousse, Tunisia


Introduction: Primary thyroid non-Hodgkin’s lymphoma, which is defined as a lymphoma occurring in the thyroid gland, is a quite rare pathologic entity, accounting for 1, 3-1, 5 % of thyroid neoplasm, and 0, 5% of lymphoma. The aim of our work is to evaluate the clinicopathological features and treatment outcomes of patients with primary thyroid lymphoma.

Material and methods: We report 8cases of primary thyroid lymphoma collected at our department between 2000 and 2023.

Results: There were 6 women and two men with an average age of 63 years. One patient had a history of neoplasia of the right breast and adenocarcinoma of the colon. The reason for consultation was an anterior basicervical swelling in all patients associated with dysphonia in one patient, dysphagia in one patient, and dyspnea in three patients. The clinical examination revealed a huge painless goiter compressive in one patient, associated with bilateral lymph nodes in two patients, and ipsilateral in a patient. One patient had an emergency tracheotomy. Four patients had biopsy and the other four patients had thyroidectomy. Histological examination concluded to a mantle lymphoma in two cases, a diffuse large B-cell lymphoma in four patients, and a MALT lymphoma in two cases. Only one patient presented an invasion of the medullary bone confirmed by biopsy. All patients underwent chemotherapy. Three patients died and 4 patients presented no recurrence.

Conclusion: Primary thyroid lymphoma is an uncommon pathologic entity. The prognosis is primarily dependent on age, staging, and disease spread, then the histologic subtype.

Keywords: autoimmune thyroiditis, hypothyroidism, euthyroidism, genetic polymorphism.

Volume 99

26th European Congress of Endocrinology

Stockholm, Sweden
11 May 2024 - 14 May 2024

European Society of Endocrinology 

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