Assessment of vitamin d status in patients with primary hyperparathyroidism: implications for clinical management

Gorgi Khaoula; Errahali Yassine; Echchad Lamya; Rifai Kaoutar; Iraqi Hinde; El Hassan Gharbi Mohamed

doi:10.1530/endoabs.99.EP483

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Endocrine Abstracts (2024) 99 EP483 | DOI: 10.1530/endoabs.99.EP483

ECE2024 Eposter Presentations Calcium and Bone (102 abstracts)

Assessment of vitamin d status in patients with primary hyperparathyroidism: implications for clinical management

Gorgi Khaoula ¹ , Errahali Yassine ² , Echchad Lamya ¹ , Rifai Kaoutar ¹ , Iraqi Hinde ¹ & Gharbi Mohamed El Hassan ¹

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¹Ibn Sina University Hospital, Endocrinology, Rabat, Morocco; ²Mohamed V Military training hospital, Endocrinology, Rabat, Morocco

Introduction: Primary hyperparathyroidism is frequently accompanied by low vitamin D levels. This study aims to assess the vitamin D status of patients diagnosed with primary hyperparathyroidism, with a focus on determining the prevalence of insufficient and deficient 25(OH) D levels in this patient population.

Patients and Methods: Conducted as a retrospective study over a 7-year period (2015-2022), our research was carried out at the endocrinology-diabetology department of CHU IBN SINA RABAT and the Mohamed V military hospital in Rabat. The study concentrated on patients hospitalized for primary hyperparathyroidism, analyzing their vitamin D levels.

Results: A total of 63 patients, with an average age of 55.8 years, were included in the study. Systematic measurement of vitamin D levels revealed a mean serum 25(OH)D level of 19.20 ng/ml. Notably, 18% of patients had vitamin D insufficiency, while 60.7% exhibited vitamin D deficiency. In patients with low vitamin D, the average serum calcium was 121.8 mg/l, and the mean parathyroid hormone (PTH) level was 261.7 ng/ml. Patients with insufficient vitamin D displayed higher PTH and blood calcium levels compared to those with normal vitamin D levels.

Discussion/Conclusion: Primary hyperparathyroidism is commonly associated with vitamin D deficiency, resulting in more pronounced bone damage and a significant elevation in blood calcium and parathyroid hormone levels. This study emphasizes the importance of vitamin D supplementation in individuals with primary hyperparathyroidism who have deficient or insufficient 25(OH)D levels.