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Endocrine Abstracts (2024) 99 EP459 | DOI: 10.1530/endoabs.99.EP459

1Clinical Centre of Montenegro, Faculty of Medicine, University of Montenegro, Montenegro;2Faculty of Medicine, Belgrade University, Serbia; Clinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Center of Serbia, Belgrade, 11 000 Belgrade, Serbia;3Clinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Center of Serbia, Belgrade, 11 000 Belgrade, Serbia


Introduction: The aim of the study was to establish the predictive factors for endocrine disease-induced hyponatremia.

Patients and methods: Fifty-two patients with hyponatremia (Na <135 nmol/l) were referred to Department of Neuroendocrinology, University Clinical Center of Serbia from January 2015 to March 2023 (n=52; 31 females, 60%) mean age 60.5±14.1 years, mean serum sodium level 124.9±9.0 mmol/l. Seven patients (13.4%) with translocational hyponatremia, caused by hyperglycemia were excluded from the analysis.

Results: No significant differences between the non-endocrine (NEhypoNa) and endocrine hyponatremia (ENhypoNa) group was detected regarding the age (P=0.439), gender (P=0.899), body mass index (P=0.236) and smoking habits (P=0.668). Compared to patients in NEhypoNa group (n=27, 60%), patients with ENhypoNa (n=18, 40%) more frequently presented with rapid-onset hyponatremia (77.8% vs 25.9%, P<0.05). Although mean serum Na was not significantly different between groups (122.8 vs 124.4 mmol/l; P=0.583), severe symptoms were predictive factors for endocrine cause, found in 77.7% of ENhypoNa patients vs 37% in NEhypoNa group (P=0.05). Hypertension was associated with non-endocrine causes of hyponatremia (66.7% in NEhypoNa vs 27.8% in ENhypoNa group; P=0.011), most commonly caused by syndrome of inappropriate diuresis (SIAD). Chronic comorbidities like type 2 diabetes, obesity and osteoporosis were more frequently present in NEhypoNa, but the sample was small so the statistical significance was not reached. In 2/3 of patients in ENhypoNa group hyponatremia unmasked previously unrecognized primary or secondary adrenal insufficiency and hypopituitarism, diagnosed in 6 (13.3%) and 12 (26.7%) patients respectively.

Conclusion: Acute and severe hyponatremia on admission with less chronic comorbidities (diabetes, obesity, hypertension, osteoporosis), more frequently reflected underlying endocrine cause of hyponatremia.

Volume 99

26th European Congress of Endocrinology

Stockholm, Sweden
11 May 2024 - 14 May 2024

European Society of Endocrinology 

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