ECE2024 Eposter Presentations Pituitary and Neuroendocrinology (214 abstracts)
Post-operative evaluation of pituitary adenomas operated at the clinical hospital of valladolid
Esther Delgado Garcia 1,2 , Juan Jose Lopez Gomez 1,2 , Paloma Perez Lopez 1,2 , Beatriz Torres Torres 1,2 , Laura Herguedas Herguedas 3 , Marta Boya Fernandez 3 & Daniel De Luis Román 1,2
1Servicio Endocrinologiay Nutricion, Hospital Clinico Universitario de Valladolid, Valladolid, Spain; 2Centro de Investigación de Endocrinología y Nutrición Clínica, Facultad de Medicina de Valladolid, Valladolid, Spain; 3Facultad de Medicina de Valladolid, Valladolid, Spain
Introduction: Pituitary adenomas are neoplasms originating in the pituitary gland. They represent 15.5% of tumor pathology of the central nervous system and their incidence is estimated at 3.4 cases per 100,000 inhabitants/year.
Objective: To evaluate the postoperative results of adenomas operated on at the Hospital Clinico de Valladolid (HCUV)
Material and Methods: Observational, transversal and retrospective study of operated adenoma from 2001 to 2016 in HCUV. Variables studied were epidemiology clinical, radiography pathology surgery radiotherapy and treatment
Results: 139 patients were evaluated, 61 (43.9%) being men with a mean age of 51 (42-63)years. The main cause of adenomas presentation was compressive symptoms (41.7%), followed by hormonal excess (26.9%) (table 1) 117 (84.2%) were macroadenomas with a mean size of 17.8 cm3 and 77.7% had suprasellar or lateral extension. The average reduction in tumor size was 32%. The immunohistochemical phenotype was performed on 64 (38.8%) tumors; the most numerous group was prolactinomas, followed by GH secreters and ACTH secreters. 11 (7.9%) patients had postsurgical complications: 8 diabetes insipidus, 2 SIADH, 1 respiratory distress. 9 patients had to undergo reoperation and 59 required radiotherapy. The long-term patient outcome was cure in 25 (18%) patients; persistence in 111 (79.9%) patients; recurrence in 2 (1.4%) patients and 1 (0.7%) patient died.
| CLINICAL PRESENTATION | N (%) |
| Compressive | 58 (41.7%) |
| Hormonal excess | 36 (25.9%) |
| Incidentaloma | 25 (18%) |
| Hormonal deficiency | 5 (3.6%) |
| Compressive/Excess | 8 (5.8%) |
| Compressive/deficit | 3 (2.2%) |
| Excess/deficit | 3 (2.2%) |
| Compressive/deficit/Excess | 1 (0.7%) |
Conclusions: Pituitary adenomas are rare lesions that manifest mainly due to compressive symptoms or hormonal hyperproduction. Those who require surgery in the hands of expert surgeons have good results
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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