ECE2024 Eposter Presentations Pituitary and Neuroendocrinology (214 abstracts)
Assessment of the effects of empty or partially empty sella on optic chiasm compression and displacement
Bernadetta Kaluza 1,2 , Furmanek Mariusz 3,4 , Domański Jan 1,2 , Żuk-Łapan Aleksandra 1,2 , Babula Emilia 1,2 , Poprawa Iga 1,2 , Landowska Małgorzata 1,2 , Jarząbek Karolina 1,2 , Popczyńska Justyna 1,2 , Filipowicz Paulina 1,2 , Wielglewska Małgorzata 1,2 , Walecki Jerzy 5 & Franek Edward 1,2,6
1National Medical Institute of the Ministry of the Interior and Administration, Department of Internal Medicine, Endocrinology and Diabetology, Warsaw, Poland; 2National Medical Institute of the Ministry of the Interior and Administration, Students Scientific Group of the Medical University of Warsaw at the Department of Internal Medicine, Endocrinology and Diabetology, Warsaw, Poland; 3National Medical Institute of the Ministry of the Interior and Administration, Department of Radiology, Warsaw, Poland; 4Medical University of Warsaw, Department of Pediatric Radiology, Warsaw, Poland; 5Centre of Postgraduate Medical Education, National Institute of Medicine of the Ministry of the Interior and Administration, Warsaw, Poland., Department of Radiology, Centre of Postgraduate Medical Education, National Institute of Medicine of the Ministry of the Interior and Administration, Warsaw, Poland., Poland; 6Mossakowski Medical Research Centre Polish Academy of Sciences, Warsaw, Poland, Department of Human Epigenetics, Warsaw, Poland
Herniation of the subarachnoid space into the sella turcica results in empty or partially empty sella syndrome. Primary sella turcica syndrome is idiopathic, whereas secondary empty sella is a result of central nervous system pathologies, which may manifest as visual disorders, due to optic chiasm compression or displacement. The purpose of this study was to determine whether empty and partially empty sella—either primary or secondary—are risk factors for optic chiasm compression. The study involved hospital database analysis and selection of 594 patients, who underwent magnetic resonance imaging of the pituitary. Empty or partially empty sella was detected in 136 patients; in 87 patients the condition was primary and in 49 it was secondary. Optic chiasm compression was found in 26 patients. The patients were divided into two groups: patients with empty/partially empty sella (group 1, n=136) and those with no empty/partially empty sella (group 2, n=458). Study groups 1 and 2 showed no statistically significant differences in terms of optic chiasm compression rates (6 [4.4%] vs 20 [4.4%], P=0.98). Univariate logistic regression demonstrated the presence of pituitary macroadenoma to be a statistically significant predictor of optic chiasm compression (OR 20.923, 95% CI 7.166–61.093, P=0.001); whereas an empty and partially empty sella, either primary (1.351, [0.42-4.342], P=0.613) or secondary (0.859, [0.174-4.24], P=0.852); Rathke cleft cyst (OR 0.307 [0.039–2.386, P=0.259), and pituitary cyst (OR 0.785 [0.168–3.656], P=0.758) are not risk factors for optic chiasm compression. Empty and partially empty sella have no effect on optic chiasm compression or displacement, which means that they may not manifest with visual symptoms, such as visual field constriction or double vision.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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