Endocrine Abstracts

Objective: Growth hormone (GH) is used for metabolic indications in the treatment of adult patients with GH deficiency (GHD). In addition to influencing growth processes in childhood, GH is important in regulating metabolic processes at every stage of life. GH, via insulin-like growth factor (IGF-1), has an anabolic effect on protein metabolism, also in skeletal muscles and cardiac muscle. Moreover, myokines produced by muscle fibers stimulated by muscle contraction, acting in an autocrine and paracrine manner, have a significant impact on metabolism. The most serious consequences of long-term, severe GHD in the adult population are the reduction of muscle and bone mass, which significantly increases the frequency of deaths due to cardiovascular complications and osteoporotic bone fractures, as well asdeteriorates the quality of life. The aim of the study is to assess the hormonal activity of muscles in adult patients treated with growth hormone: with confirmed growth hormone deficiency after a growth-promoting period and with Prader Willi syndrome. The project also aims to assess the impact of treatment on quality of life and physical condition. Patients with GHD who require GH therapy are classified into two groups: GHD that occurred in childhood (childhood-onset GHD - CO-GHD) and GHD acquired in adulthood (AO-GHD, adult-onset GHD).Designobservational, cohort-prospectivePatientsStudy participants: Patients with Prader Willi syndrome, patients with growth hormone deficiency, qualified for recombinant human growth hormone (rhGH)treatment and healthy volunteers.Measurements A subjective and physical examination was performed, assessing height, weight, BMI, body composition using the bioimpedance method, and assessing muscle, fat and bone tissue. Quality of life questionnaires, SF-36 and (QoL-AGRDA) were administered. Biochemical and hormonal determinations were made, including (IGF-1) and determinations of myokines like Irisin, Myostatin, IL4, I8, L6, IL15, Apelin and proteins binding insulin-like growth factor (IGFBP-3)ResultsThe data obtained in the study allowed us to examine the impact on the hormonal activity of muscles and their function in patients undergoing treatment with human recombinant growth hormone. Hormonal activity of muscles influences metabolic processes and quality of life in patients treated with growth hormone.

Conclusions: Growth hormone deficiency in adults requires precise diagnostics and properly conducted substitution treatment