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Endocrine Abstracts (2024) 99 EP208 | DOI: 10.1530/endoabs.99.EP208

ECE2024 Eposter Presentations Pituitary and Neuroendocrinology (214 abstracts)

Oral health-related quality of life in patients with acromegaly vs patients with non-functioning pituitary adenomas

Sandra Blum 1 , Linda Daume 2 , Rohith Illuri 1 , Johannes Kleinheinz 2 , Jonel Trebicka 1 & Elena Vorona 1


1Münster University Hospital, Gastroenterology, Hepatology, Endocrinology, Infectiology, Münster, Germany; 2Münster University Hospital, Cranio-Maxillofacial Surgery, Münster, Germany


Introduction: Acromegaly is a rare endocrinologic disease most commonly caused by an excess of growth hormone (GH) produced by a benign pituitary adenoma. Besides diverse systemic manifestations, acromegaly is also associated with a range of oral-dental problems. To date limited research has been conducted on how oral-dental pathologies affect the oral health-related quality of life (OHRQoL) in patients with acromegaly and growth hormone-producing pituitary adenomas. To our knowledge this is the first study which compares the OHRQoL between acromegaly patients and those with non-functioning pituitary adenomas. The aim of this study is to improve understanding of acromegaly’s dental effects and the impact of OHRQoL and to enhance future treatment and patient outcomes.

Methods: 41 patients with diagnosis of growth hormone-producing pituitary adenomas and patients with non-functioning pituitary adenoma were included in the study. All participants were asked to complete a german version of the oral health impact profile 14 questionnaire (OHIP-14). For included patients data from the clinical profile were collected. Comparative analysis of both groups were performed. Patients diagnosed with acromegaly and growth hormone-producing pituitary adenomas were additionally examined in regard of their oral-dental health condition by a speacialist and had to answer 3 additional questions referring to their oral-dental care by dentist. Based on the examination, a specialist medical diagnostic of the problem and, if necessary, appropriate treatment is offered.

Results: Mean age of the acromegalic patients was 55,95 years and 26 patients were females. The average OHIP-14 score for an acromegalic patient was 9,95 points. Female acromegalic patients present a higher OHIP-14 Score (12.15 points) than males (6.13 points). The questionnaire domains most affected were psychological discomfort (mean 2.05±2.27) and psychological disability (mean 2.05±2.07) and physical pain (mean 1.53±1.7). 89.7% of acromegalic patients are satisfied with dental care and 95% had no difficulty finding a dentist due to acromegaly. However, 77.4% of acromegaly patients have the impression that the dentist is not familiar with their disease.

Conclusion: the analyses of our data will take a crucial step forward in providing deeper insights into the impact of oral health conditions and associated comorbidities as well as OHRQoL in patients with acromegaly.

Volume 99

26th European Congress of Endocrinology

Stockholm, Sweden
11 May 2024 - 14 May 2024

European Society of Endocrinology 

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