ECE2024 Eposter Presentations Diabetes, Obesity, Metabolism and Nutrition (383 abstracts)
Fatal rhinosinus disease in diabetic patients: about 8 cases
El Omri Malika 1 , Jemli S 1 , Lazid Sarra 1 , Bellakhdher Mouna 1 , Meherzi Abir 1 , Houas Jihene 1 , Ghammem Monia 1 , Ach Taieb 2 , Kermani Wassim 1 & Abdelkefi Mohamed 1
1ENT department Farhat Hached hospital, Sousse, Tunisia; 2Endocrinology department Farhat Hached hospital, Sousse, Tunisia
Introduction: Mucormycosis is a rare opportunistic aggressive fungal infection usually occurs patients with immune deficiency especially in diabetic. Extension is rapid, with a high rate of mortality. The pathogen is a filamentous fungus of the zygomycete class of the Mucorales order. The aim of this study to reveal clinical, paraclinical manifestations of this entity and its prognosis.
Material and methods: A retrospective study about 8 cases of mucormycosis diagnosed and treated in our ENT department between January 2000 and December 2023
Results: The mean age was 49 years with male predominance, the average duration of diabetes follow up was over 12 years. We noticed an orbital involvement in one case. Rhinocerebral mucormycosis was diagnosed in one patient. The infection was limited to the rhinosinus space in 6 cases. The causative agent was, exclusively, Rhizopusarrhizus. In all cases, surgical evaluation was immediately performed for debridement of the necrotic tissues, and multiple biopsies were performed for diagnostic purposes. The medical treatment was based in intravenous liposomal amphotericin B. The main complication was septicemia, seen in one case, after one week of evolution. We noted a complete recovery in 5 cases. Outcomes had been marked by the death of one patient who had a cerebral involvement.
Conclusion: ENT mucormycosis is a rare and severe fungal infection, to be borne in mind in diabetic patients. Late diagnosis and treatment inevitably incurs severe or even fatal complications. Only adequate early treatment, associating amphotericin B, necrotic tissue resection and control of risk factors can improve prognosis.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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